The hospital ward's environment directly impacts the health and well-being of its occupants, especially patients. This study investigated the impacts of environmental factors (thermal, acoustic, luminous, and IAQ) and selfdescribed health conditions on subjective environmental perception and satisfaction in hospital wards. A winter field survey of 156 occupants (patients and visitors) was conducted in a large general hospital in Changsha, China, using a combination of environment measurements, questionnaires, and interviews. The results showed comprehensive effects of environmental factors on occupants' perceptions. Lower air temperature improved participants' assessment of the acoustic environment; lower noise environment led to a positive assessment of IAQ perception; lower CO2 concentration improved the assessment of the thermal environment in a hotter environment. Acoustic perception (13.4 %), IAQ perception (10.5 %), and luminous perception (8.2 %) were significantly affected by health conditions. Moreover, the poorer the health condition, the lower the environmental satisfaction rating, and the acceptable environmental thresholds differed for individuals with various health conditions. The "very weak" group scored 1.6 and 1.5 points lower than the "very fit" for each environmental factor and overall satisfaction, respectively. For IEQ control in healthcare facilities, it is necessary to fully consider patients' health conditions during hospitalization and create a better recuperation environment for vulnerable groups.