Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism

被引:4
|
作者
Munyoki, Sarah K. [1 ,2 ,3 ]
Goff, Julie P. [1 ,2 ,3 ]
Kolobaric, Antonija [4 ]
Long, Armari [1 ,2 ,3 ]
Mullett, Steven J. [5 ,6 ]
Burns, Jennifer K. [7 ,8 ]
Jenkins, Aaron K. [7 ,8 ]
DePoy, Lauren [7 ,8 ]
Wendell, Stacy G. [5 ,6 ]
McClung, Colleen A. [4 ,7 ,8 ]
Morrison, Kathleen E. [9 ]
Jasarevic, Eldin [1 ,2 ,3 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Computat & Syst Biol, Pittsburgh, PA 15213 USA
[3] Magee Womens Res Inst, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Ctr Neurosci, Pittsburgh, PA 15260 USA
[5] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA
[6] Univ Pittsburgh, Hlth Sci Mass Spectrometry Core, Sch Med, Pittsburgh, PA USA
[7] Univ Pittsburgh, Sch Med, Clin & Translat Sci Inst, Pittsburgh, PA USA
[8] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
[9] West Virginia Univ, Dept Psychol, Morgantown, WV USA
关键词
CHAIN FATTY-ACIDS; GUT MICROBIOTA; GENETIC ARCHITECTURE; DIURNAL RHYTHMS; DIETARY FIBER; OBESITY; CLOCK; EXPRESSION; HEALTH; MICE;
D O I
10.1016/j.isci.2023.107999
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Circadian rhythms dynamically regulate sex differences in metabolism and immunity, and circadian disruption increases the risk of metabolic disorders. We investigated the role of sex-specific intestinal microbial circadian rhythms in host metabolism using germ-free and conventionalized mice and manipulation of dietary-derived fat, fiber, and microbiota-accessible carbohydrates. Our findings demonstrate that sex differences in circadian rhythms of genes involved in immunity and metabolism depend on oscillations in microbiota, microbial metabolic functions, and microbial metabolites. Further, we show that consuming an obesogenic, high-fat, low-fiber diet produced sex-specific changes in circadian rhythms in microbiota, metabolites, and host gene expression, which were linked to sex differences in the severity of metabolic dysfunction. Our results reveal that microbial circadian rhythms contribute to sex differences in immunity and metabolism and that dietary factors can entrain new circadian rhythms and modify the magnitude of sex differences in host-microbe circadian dynamics.
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收藏
页数:21
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