Crossing the Non-Human Primate Blood Brain Barrier with Machine-Guided AAV Capsid Design

被引：0
|
作者：
Bailey, Megan Elizabeth [1 ]
Bloodgood, Dan [1 ]
Chen, Ina [1 ]
Gerold, Jeff [1 ]
Holth, Jerrah [1 ]
Jajoo, Rishi [1 ]
Kelsic, Eric [1 ]
Lin, Kathy S. [1 ]
McDonel, Patrick [1 ]
Vihani, Aashu [1 ]
Wolock, Sam [1 ]
机构：
[1] Dyno Therapeut, Watertown, MA USA
来源：
MOLECULAR THERAPY | 2023年 / 31卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
382
引用
收藏
页码：204 / 204
页数：1
相关论文
共 50 条
  • [1] Optimizing Intravitreal Delivery to the Non-Human Primate Retina with Machine-Guided AAV Capsid Design
    Abesteh, Shireen
    Brenckle, Ian
    Cargill, Zac
    Chen, Ina
    Chen, Sam
    Deny, Daniela
    Fathima, Jumana
    Gerold, Jeff
    Ghosh, Arpan
    Grush, Jacob
    Kelsic, Eric
    Kuchwara, Helene Marie
    Kwasnieski, Jamie
    Lin, Kathy S.
    Lykken, Erik A.
    Marrogi, Eryney
    Maryak, Katie
    McDonel, Patrick
    Levitin, Hanna Mendes
    Miles, Amanda
    Nagabhushana, Nishith
    Pignatta, Daniela
    Satinsky, Brandon
    Saxena, Bhavica
    Sengel, Cem
    Sheridan, Abigail Rose
    Tarbell, Timothy
    Thommes, Meghan
    Turunen, Heikki
    White, Nick
    Wolock, Sam
    MOLECULAR THERAPY, 2023, 31 (04) : 610 - 610
  • [2] Machine-Guided Design of AAV Capsid Proteins with Experimentally Augmented Evolutionary Data
    Sinai, Sam
    Kelsic, Eric
    Tan, Javen
    Jain, Nina
    Ogden, Pierce
    Nowak, Martin
    Church, George M.
    MOLECULAR THERAPY, 2019, 27 (04) : 52 - 52
  • [3] Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
    Ogden, Pierce J.
    Kelsic, Eric D.
    Sinai, Sam
    Church, George M.
    SCIENCE, 2019, 366 (6469) : 1139 - +
  • [4] A Novel AAV Capsid with a Potential of Crossing NHP Blood-Brain Barrier
    Li, Shaoyong
    Wang, Wei
    Lu, Xiaodong
    Wang, Hongxing
    Huang, Carol
    Tocci, Jenna
    Ren, Xiaoqin
    Ren, Amy
    Shang, Jianyu
    Zhou, Pengcheng
    Hefferan, Michael
    Nonnenmacher, Mathieu
    Cabral, Joseph
    Hou, Jay
    MOLECULAR THERAPY, 2020, 28 (04) : 253 - 253
  • [5] Evaluation of a Human Neurovascular Model to Complement a Parallel Non-Human Primate Selection for Blood Brain Barrier Penetrant AAV Capsids
    Tiffany, Matthew R.
    Frias, Stephanye
    Goodwin, Alicia
    Ward, Alex
    Tran, Hung
    Prawdzik, Gregg
    Kennard, Kenneth
    Ojala, David S.
    Zeitler, Bryan J.
    Pooler, Amy M.
    MOLECULAR THERAPY, 2022, 30 (04) : 425 - 425
  • [6] Discovery of Highly Epistatic AAV Capsid Variants Through Machine-Guided Navigation of the Fitness Landscape
    Sinai, Sam
    Gane, Andreea
    Jain, Nina
    Bileschi, Max
    Bryant, Drew
    Bashir, Ali
    Church, George
    Kelsic, Eric
    Colwell, Lucy
    MOLECULAR THERAPY, 2022, 30 (04) : 429 - 429
  • [7] AAV Capsid Selection at Spatial and Single-Cell Resolution in Non-Human Primate Retina
    Robbins, Ashley
    Chen, Yonghong
    Lewandowski, Brian
    Houserova, Dominika
    Ranum, Paul T.
    Tecedor, Luis
    Davidson, Beverly L.
    MOLECULAR THERAPY, 2024, 32 (04) : 166 - 167
  • [8] Evolution of Blood-Brain Barrier Penetrant AAV Capsids in Non-Human Primates Using a Multiplexed Transcription Dependent Capsid Engineering Platform
    Tiffany, Matthew R.
    Frias, Stephanye
    Andrews, Lori
    Nanjaraj, Ankitha
    Bendana, Yuri
    Darst, Russell
    Wist, Stephen
    Tran, Hung
    Kennard, Kenneth
    Mueller, Sarah
    Ojala, David
    Pooler, Amy
    MOLECULAR THERAPY, 2023, 31 (04) : 573 - 573
  • [9] Axonal transport of a modified AAV2 in the non-human primate brain
    Ohno, K.
    Stanek, L. M.
    Naidoo, J.
    Trewman, S.
    Samaranch, L.
    Hadaczek, P.
    O'Riordan, C.
    Sullivan, J.
    San Sebastian, W.
    Bringas, J. R.
    Snieckus, C.
    Mahmoodi, A.
    Mahmoodi, A.
    Forsayeth, J.
    Shihabuddin, L. S.
    Bankiewicz, K. S.
    HUMAN GENE THERAPY, 2018, 29 (12) : A153 - A153
  • [10] A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system
    Kondratov, Oleksandr
    Kondratova, Liudmyla
    Mandel, Ronald J.
    Coleman, Kirsten
    Savage, Michael A.
    Gray-Edwards, Heather L.
    Ness, Timothy J.
    Rodriguez-Lebron, Edgar
    Bell, Robert D.
    Rabinowitz, Joseph
    Gamlin, Paul D.
    Zolotukhin, Sergei
    MOLECULAR THERAPY, 2021, 29 (09) : 2806 - 2820
12345