ARE MEDIUM CUT-OFF MEMBRANES THE FUTURE, OR THE PROMISING REALITY FOR CHRONIC HEMODIALYSIS PATIENTS?

被引：0
|
作者：
Del Toro-Cisneros, Noemi [1 ]
Zuniga-Gonzalez, Erick Y. [1 ]
Caballero-Islas, Adrian E. [1 ]
Geraldo-Murillo, Jose A. [1 ]
Arvizu-Hernandez, Mauricio [1 ,2 ]
Vega-Vega, Olynka [1 ]
机构：
[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, Mexico
[2] Tecnol Monterrey, Sch Med & Hlth Sci, Monterrey, NL, Mexico
来源：
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION | 2023年 / 75卷 / 06期
关键词：
Medium cut-off dialyzers; Online-hemodiafiltration; Chronic hemodialysis; Internal filtration-back filtration mechanism; Middle molecules; EXPANDED HEMODIALYSIS; OXIDATIVE STRESS; ASSOCIATION; DIALYSIS; THERAPY; IMPACT; NEEDS;
D O I：
10.24875/RIC.23000213
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The development of hemodialysis (HD) membranes has substantially advanced in the last decade. This has resulted in the manufacturing of medium cut-off membranes (MCO) whose internal architecture is based on greater pore size and a smaller diameter, thus promoting the clearance of particles of greater size as well as retrofiltration. Multiple studies have proven their efficacy in the clearance of uremic mid-sized molecules such as beta 2-microglobulin, free light chains, and some interleukins; this clearance is far superior with MCO membranes when compared with high-flux HD, and similar to that obtained with online hemodiafiltration. This review summarizes the results of the most relevant clinical studies of this membrane in terms of uremic toxin clearance, as well as the features of some clinical outcomes such as quality of life and hospitalizations.
引用
收藏
页码：289 / 299
页数：11
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