Aqueous Fabrication and Biomedical Applications of Supraparticles

Supraparticles(SPs) are the nano-entities self-assembled by one or multiple nanoparticle based on internal or external driving forces, which possess specific morphology, definite size, and hierarchical structure. Due to the complex topologies, abundant surface modifiability, tunable collective properties, and synergistic effects, SPs have considerable potentials in the biomedical field. Here, recent progress of SPs synthesized in aqueous phase, including the force modulation between building blocks, the property of SPs, and their applications in biological imaging, disease diagnosis, and therapy, is reviewed. Finally, the main challenges and future advancement in aspects of the precise regulation of the structure and properties of SPs, as well as biomedical applications are discussed.