The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice

被引:17
|
作者
Frontera, Jimena L. [1 ]
Sala, Romain W. [1 ]
Georgescu, Ioana A. [1 ]
Aissa, Hind Baba [1 ]
d'Almeida, Marion N. [1 ]
Popa, Daniela [1 ]
Lena, Clement [1 ]
机构
[1] PSL Res Univ, Ecole Normale Super, Inst Biol Ecole Normale Super IBENS, Neurophysiol Brain Circuits Team,CNRS,INSERM, F-75005 Paris, France
关键词
MEDIODORSAL THALAMIC NUCLEUS; PREFRONTAL CORTEX; FUNCTIONAL TOPOGRAPHY; NEURONAL CIRCUITS; RAT; SYNCHRONIZATION; CONNECTIVITY; TRANSMISSION; ORGANIZATION; METAANALYSIS;
D O I
10.1038/s41467-023-36943-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Fear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction. Fear extinction is a learning process controlled by the prefrontal cortex. Here, authors show that the cerebellum regulates fear extinction via projections to the medio-dorsal thalamus and the modulation of thalamo-prefrontal cortex interactions.
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页数:16
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