Therapeutic implications of cancer stem cells in prostate cancer

被引：12

作者：

Banerjee, Pinaki ^{[1
]}

Kapse, Prachi ^{[2
]}

Siddique, Shehnaz ^{[3
]}

Kundu, Moumita ^{[3
]}

Choudhari, Jasoda ^{[4
]}

Mohanty, Varshasnata ^{[3
]}

Malhotra, Diksha ^{[3
]}

Gosavi, Suresh W. ^{[2
]}

Gacche, Rajesh N. ^{[4
]}

Kundu, Gopal C. ^{[3
,5
]}

机构：

[1] Natl Ctr Cell Sci, Savitribai Phule Pune Univ Campus, Pune 411007, India

[2] Savitribai Phule Pune Univ, Sch Basic Med Sci, Pune 411007, India

[3] KIIT Deemed Univ, Sch Biotechnol, Bhubaneswar 751024, India

[4] Savitribai Phule Pune Univ, Dept Biotechnol, Pune 411007, India

[5] KIIT Deemed Univ, Kalinga Inst Med Sci KIMS, Bhubaneswar 751024, India

来源：

CANCER BIOLOGY & MEDICINE | 2023年 / 20卷 / 06期

关键词：

Epithelial-mesenchymal transition; metastasis; prostate cancer; cancer stem cells; tumor growth; tumor microenvironment; signaling; METHYLACYL-COA RACEMASE; HIPPO SIGNALING PATHWAY; AMINO-ACID-TRANSPORT; ANDROGEN RECEPTOR; LIPID-METABOLISM; EPITHELIAL-CELLS; TUMOR INITIATION; REPORTER SYSTEM; DRUG-RESISTANCE; LUMINAL CELLS;

D O I：

10.20892/j.issn.2095-3941.2022.0714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.

引用

页码：401 / 420

页数：20

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