A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic

被引：4

作者：

Goryunov, Kirill ^{[1
]}

Ivanov, Mikhail ^{[1
,2
]}

Kulikov, Andrey ^{[3
]}

Shevtsova, Yulia ^{[1
,2
]}

Burov, Artem ^{[1
]}

Podurovskaya, Yulia ^{[1
]}

Zubkov, Victor ^{[1
]}

Degtyarev, Dmitry ^{[1
]}

Sukhikh, Gennady ^{[1
]}

Silachev, Denis ^{[1
,2
]}

机构：

[1] VI Kulakov Natl Med Res Ctr Obstet Gynecol & Perin, Moscow 117198, Russia

[2] Lomonosov Moscow State Univ, AN Belozersky Inst Phys Chem Biol, Moscow 119992, Russia

[3] RUDN Univ, Patrice Lumumba Peoples Friendship Univ Russia, Med Inst, Moscow 117198, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 05期

关键词：

extracellular vesicles; mesenchymal stromal cells; neonatal pathologies; premature newborns; cell therapy; MESENCHYMAL STEM-CELLS; COMPREHENSIVE PROTEOMIC ANALYSIS; ISCHEMIA-REPERFUSION INJURY; BREAST-MILK; BRONCHOPULMONARY DYSPLASIA; EXOSOMES PROTECT; DENDRITIC CELLS; BRAIN-INJURY; LUNG INJURY; MOUSE-BRAIN;

D O I：

10.3390/ijms25052879

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neonatal disorders, particularly those resulting from prematurity, pose a major challenge in health care and have a significant impact on infant mortality and long-term child health. The limitations of current therapeutic strategies emphasize the need for innovative treatments. New cell-free technologies utilizing extracellular vesicles (EVs) offer a compelling opportunity for neonatal therapy by harnessing the inherent regenerative capabilities of EVs. These nanoscale particles, secreted by a variety of organisms including animals, bacteria, fungi and plants, contain a repertoire of bioactive molecules with therapeutic potential. This review aims to provide a comprehensive assessment of the therapeutic effects of EVs and mechanistic insights into EVs from stem cells, biological fluids and non-animal sources, with a focus on common neonatal conditions such as hypoxic-ischemic encephalopathy, respiratory distress syndrome, bronchopulmonary dysplasia and necrotizing enterocolitis. This review summarizes evidence for the therapeutic potential of EVs, analyzes evidence of their mechanisms of action and discusses the challenges associated with the implementation of EV-based therapies in neonatal clinical practice.

引用

页数：35