Tiny Drosophila intestinal stem cells, big power

被引：2
|
作者：
Zhai, Jingbo [1 ,2 ,3 ]
Li, Wanyang [1 ]
Liu, Xin [1 ,2 ,3 ]
Wang, Di [1 ,2 ,3 ]
Zhang, Dongli [1 ,2 ,3 ]
Liu, Yanli [4 ]
Liang, Xiuwen [5 ]
Chen, Zeliang [1 ,2 ,3 ]
机构：
[1] Inner Mongolia Minzu Univ, Med Coll, Tongliao 028000, Peoples R China
[2] Key Lab Zoonose Prevent & Control Univ Inner Mong, Tongliao, Peoples R China
[3] Brucellosis Prevent & Treatment Engn Res Ctr Inne, Tongliao, Peoples R China
[4] Inner Mongolia Minzu Univ, Affiliated Hosp, Tongliao, Peoples R China
[5] Hulunbuir City Peoples Hosp, Hulunbuir City 021008, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2023年 / 47卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Drosophila; microbiota; midgut; signaling crosstalk; stem cells; TISSUE HOMEOSTASIS; HIPPO PATHWAY; DUAL OXIDASE; LIFE-SPAN; PROLIFERATION; MIDGUT; DIVISION; GUT; DIFFERENTIATION; GROWTH;
D O I：
10.1002/cbin.11911
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The signaling pathways are highly conserved between Drosophila and mammals concerning intestinal development, regeneration, and disease. The powerful genetic tools of Drosophila make it a valuable and convenient alternative to answer basic biological questions that can not be addressed using mammalian models. In this review, we discuss recent advances in how we use fly midgut to answer the following key questions: (1) How intestine stem cell niches are established; (2) which factors control asymmetric division of stem cells; (3) how intestinal cells interact with environmental factors, such as tissue damage, microbiota, and diet; (4) how to screen aging/cancer-related factors or drugs by fly intestine stem cells.
引用
收藏
页码：3 / 14
页数：12
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