Emerging role and function of SPDL1 in human health and diseases

被引：0
|
作者：
Feng, Yuejiao [1 ,2 ,3 ]
Tang, Donghao [1 ,2 ,3 ]
Wang, Jie [1 ,2 ,3 ]
机构：
[1] Anhui Med Univ, Shanghai Putuo Cent Sch Clin Med, Shanghai 200062, Peoples R China
[2] Anhui Med Univ, Sch Clin Med 5, Hefei 230022, Anhui, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Dept Gen Surg, Putuo Hosp, Shanghai 200062, Peoples R China
来源：
OPEN MEDICINE | 2024年 / 19卷 / 01期
关键词：
cancer; CCDC99; cell cycle; hSpindly; SPDL1; SPINDLE ASSEMBLY CHECKPOINT; CELL-CYCLE; CHROMOSOME SEGREGATION; DYNEIN; COMPLEX; PROTEIN; FARNESYLATION; KINETOCHORES; INSTABILITY; MECHANISMS;
D O I：
10.1515/med-2024-0922
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
SPDL1 (spindle apparatus coiled-coil protein 1), also referred to as CCDC99, is a recently identified gene involved in cell cycle regulation. SPDL1 encodes a protein, hSpindly, which plays a critical role in the maintenance of spindle checkpoint silencing during mitosis. hSpindly coordinates microtubule attachment by promoting kinesin recruitment and mitotic checkpoint signaling. Moreover, the protein performs numerous biological functions in vivo and its aberrant expression is closely associated with abnormal neuronal development, pulmonary interstitial fibrosis, and malignant tumor development. In this review, we provide an overview of studies that reveal the characteristics of SPDL1 and of the protein encoded by it, as well as its biological and tumor-promoting functions.
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页数：9
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