Ultrasound-Mediated Green Synthesis of Imidazo[1,2-a ]pyridines and Imidazo[2,1-b ]thiazoles through C(sp 3 )-H Functionalization

被引：0

作者：

Chauhan, Swati ^{[1
]}

Verma, Pratibha ^{[2
]}

Srivastava, Vandana ^{[2
]}

机构：

[1] Gautam Buddha Univ, Sch Vocat Studies & Appl Sci, Dept Appl Chem, Greater Noida 201312, India

[2] Indian Inst Technol BHU, Dept Chem, Varanasi 221005, India

来源：

SYNLETT | 2024年 / 35卷 / 16期

关键词：

green chemistry; heterocycles; gram-scale synthesis; ultrasound; one-pot synthesis; ONE-POT SYNTHESIS; CATALYZED SYNTHESIS; POTASSIUM-IODIDE; DERIVATIVES; ACCESS; CONSTRUCTION; INHIBITORS; DISCOVERY; ALDEHYDES; LIGAND;

D O I：

10.1055/s-0042-1751565

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An ultrasound-assisted expedient protocol has been developed for the synthesis of imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazoles by the C-H functionalization of ketones using a KI/tert-butylhydroperoxide catalytic system. The reaction takes place in water, agreen solvent, and does not require a metal catalyst; it also gives goodyields of the products. The method offers numerous noteworthy char-acteristics, including mild reaction conditions, the absence of a base,broad functional-group compatibility, and excellent reaction yields.Moreover, it avoids the use of costly and air-sensitive chemicals, andcan be conducted under ambient reaction conditions.

引用

页码：1899 / 1905

页数：7

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