CLINICAL DEVELOPMENT OF A NOVEL CD5 KNOCKED OUT ANTI-CD5 CAR T CELL PRODUCT FOR T CELL LYMPHOMA

被引：0
|
作者：
Patel, R. [1 ]
Ghilardi, G. [1 ]
Porazzi, P. [1 ]
Yang, S. [2 ]
Qian, D. [2 ]
Zhang, Y. [1 ]
Pajarillo, R. [1 ]
Schuster, S. [3 ]
Barta, S. [3 ]
Nimmagadda, A. [2 ]
Snook, A. [2 ]
Siciliano, N. [2 ]
Ruella, M. [1 ]
机构：
[1] Univ Penn, Ctr Cellular Immunotherapies, Philadelphia, PA USA
[2] ViTToria Biotherapeut, Philadelphia, PA USA
[3] Univ Penn, Dept Med, Philadelphia, PA USA
来源：
CYTOTHERAPY | 2023年 / 25卷 / 06期
关键词：
Chimeric antigen receptor; T cell lymphoma; CRISPR Cas9;
D O I：
暂无
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
1072
引用
收藏
页码：S248 / S248
页数：1
相关论文
共 50 条
  • [1] Clinical Development of Senza5™ CART5: a Novel Dual Population CD5 CRISPR-Cas9 Knocked out Anti-CD5 Chimeric Antigen Receptor T Cell Product for Relapsed and Refractory CD5+Nodal T-Cell Lymphomas
    Patel, Ruchi P.
    Ghilardi, Guido
    Porazzi, Patrizia
    Yang, Steven
    Qian, Dean
    Pajarillo, Raymone
    Wang, Michael
    Zhang, Yunlin
    Schuster, Stephen J.
    Barta, Stefan K.
    Nimmagadda, Aditya
    Snook, Adam
    Siciliano, Nicholas A.
    Ruella, Marco
    BLOOD, 2022, 140 : 1604 - 1605
  • [2] Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells
    Jia Feng
    Haichan Xu
    Andrew Cinquina
    Zehua Wu
    Qi Chen
    Ping Zhang
    Xingen Wang
    Huiming Shan
    Lei Xu
    Qian Zhang
    Lihua Sun
    Wenli Zhang
    Kevin G. Pinz
    Masayuki Wada
    Xun Jiang
    William M Hanes
    Yupo Ma
    Hongyu Zhang
    Stem Cell Reviews and Reports, 2021, 17 : 652 - 661
  • [3] Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells
    Feng, Jia
    Xu, Haichan
    Cinquina, Andrew
    Wu, Zehua
    Chen, Qi
    Zhang, Ping
    Wang, Xingen
    Shan, Huiming
    Xu, Lei
    Zhang, Qian
    Sun, Lihua
    Zhang, Wenli
    Pinz, Kevin G.
    Wada, Masayuki
    Jiang, Xun
    Hanes, William M.
    Ma, Yupo
    Zhang, Hongyu
    STEM CELL REVIEWS AND REPORTS, 2021, 17 (02) : 652 - 661
  • [4] Characterization of an Anti-CD5 Directed CAR T-Cell against T-Cell Malignancies
    Masayuki Wada
    Hongyu Zhang
    Liu Fang
    Jia Feng
    Charlotte Olivia Tse
    Wenli Zhang
    Qi Chen
    Sha Sha
    Yuanzhen Cao
    Kevin H. Chen
    Kevin G. Pinz
    Xi Chen
    Xing-Xing Fan
    Xun Jiang
    Yupo Ma
    Stem Cell Reviews and Reports, 2020, 16 : 369 - 384
  • [5] CD5 KNOCKOUT ENHANCES THE POTENCY OF MULTIPLEX BASE-EDITED ALLOGENEIC ANTI-CD5 CAR T-CELL THERAPY FOR THE TREATMENT OF T-CELL MALIGNANCIES
    Yang, Yinmeng
    Murray, Ryan
    Camblin, Adam
    Musenge, Faith
    Coholan, Lindsey
    Naniong, MarkVic
    Sweezy, David
    Haskett, Scott
    Young, Lauren
    Zhang, Yingying
    Costa, Amanda
    Wu, Hui
    Ladd, Alden
    Barrera, Luis
    Schlehuber, Lisa
    Smith, Sarah
    Poh, Yeh-Chuin
    Ciaramella, Giuseppe
    Gehrke, Jason
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A165 - A165
  • [6] Characterization of an Anti-CD5 Directed CAR T-Cell against T-Cell Malignancies
    Wada, Masayuki
    Zhang, Hongyu
    Fang, Liu
    Feng, Jia
    Tse, Charlotte Olivia
    Zhang, Wenli
    Chen, Qi
    Sha, Sha
    Cao, Yuanzhen
    Chen, Kevin H.
    Pinz, Kevin G.
    Chen, Xi
    Fan, Xing-Xing
    Jiang, Xun
    Ma, Yupo
    STEM CELL REVIEWS AND REPORTS, 2020, 16 (02) : 369 - 384
  • [7] CD5 Expression in Mature T Cell Lymphoma
    Cao, Miao
    Tavakkoli, Montreh
    Chong, Elise A.
    Carter, Jordan S.
    Ruella, Marco
    Landsburg, Daniel J.
    Nasta, Sunita D.
    Svoboda, Jakub
    Schuster, Stephen J.
    Barta, Stefan K.
    BLOOD, 2023, 142
  • [8] Mitigating the CD5 CAR-CD5 interaction enhances the functionality of CD5 CAR-T cells by alleviating the T-cell fratricide
    Ho, Lee Young
    Yu, Seung Rok
    Jeong, Hoon Jeong
    Lee, Hyeong Ji
    Cho, Hyeon Jeong
    Kim, Hyung Cheol
    CANCER RESEARCH, 2023, 83 (07)
  • [9] CD5 CAR for the Treatment of T-Cell Malignancies
    Mamonkin, Maksim
    Brenner, Malcolm K.
    MOLECULAR THERAPY, 2015, 23 : S162 - S163
  • [10] Functions of CD5 in T cell activation and development
    Zuckerman, LA
    Ferris, W
    Dennehy, K
    Beyers, A
    Killeen, N
    FASEB JOURNAL, 1998, 12 (04): : A304 - A304
12345