Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review

被引：4

作者：

Niu, Jing ^{[1
,2
,3
]}

Liu, Yanli ^{[2
,3
]}

Wang, Junjun ^{[2
,3
]}

Wang, Hui ^{[2
,3
]}

Zhao, Ying ^{[2
,3
,4
]}

Zhang, Min ^{[2
,3
]}

机构：

[1] Northwest Univ, Coll Life Sci & Med, Xian, Peoples R China

[2] Fourth Mil Med Univ, Sch Stomatol, State Key Lab Mil Stomatol, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Natl Clin Res Ctr Oral Dis, Sch Stomatol, Dept Gen Dent & Emergency, Xian 710032, Peoples R China

[4] Northwest Univ, Xian Peoples Hosp, Xian Hosp 4, Dept Anesthesiol & Perioperat Med, Xian, Peoples R China

来源：

MEDICINE | 2023年 / 102卷 / 17期

基金：

中国国家自然科学基金;

关键词：

articular cartilage; regeneration; repair; thrombospondin-2 (TSP-2); MESENCHYMAL STEM-CELLS; INDUCED SECRETED PROTEIN; CHONDROCYTE DIFFERENTIATION; MATRICELLULAR PROTEIN; ARTICULAR-CARTILAGE; EXPRESSION; OSTEOARTHRITIS; GROWTH; REPAIR; MICE;

D O I：

10.1097/MD.0000000000033651

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are typically used to induce cartilage differentiation in stem cells. The role of thrombospondin-2 in cartilage formation has received much attention in recent years. This paper reviews the role of thrombospondin-2 in cartilage regeneration and the important role it plays in protecting cartilage from damage caused by inflammation or trauma and in the regenerative repair of cartilage by binding to different receptors and activating different intracellular signaling pathways. These studies provide new ideas for cartilage repair in clinical settings.

引用

页数：7

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