Two New Phenolic Compounds from Polygonatum cyrtonema Flowers and Their Aldose Reductase Inhibitory Activities

被引：1
|
作者：
Tang, Yi-Yuan [1 ]
Zhang, Yu-Qian [1 ]
Chen, Jia [1 ]
Zhao, Chun-Chao [1 ]
Fan, Ju-Di [2 ]
Shao, Jian-Hua [1 ]
机构：
[1] Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou 225009, Peoples R China
[2] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550004, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Liliaceae; Polygonatum cyrtonema; phenolic compound; aldose reductase inhibition;
D O I：
10.1007/s10600-023-03916-w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new phenolic compounds, (1R,2R)-1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol (1) and (1S,2S)-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-ethoxypropan-2-ol (2), and one known analog (3) have been isolated from the methanol extract of Polygonatum cyrtonema Hua flowers and identified by H-1 NMR, C-13 NMR, HSQC, HMBC, HR-ESI-MS, and optical rotations. In addition, compounds 1-3 displayed potential aldose reductase inhibitory activity with IC50 values of 22.16, 17.63, and 28.74 mu M, respectively.
引用
收藏
页码：56 / 58
页数：3
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