Palladium/Norbornene Cooperative-Catalyzed Cascade Decarboxylative Cyclization of 4-Iodoisoquinolin-1(2H)-ones with o-Bromobenzoic Acids: Access to Diverse Fused Phenanthridinones and Hepta[1,2-c]isoquinolinones

被引：5

作者：

Huang, Xiao-Hong ^{[2
]}

Yang, Cai-Yun ^{[2
]}

Liu, Feng-Lin ^{[2
]}

Li, Xia ^{[1
]}

Liu, Bo ^{[2
]}

Kou, Jun-Feng ^{[2
]}

Huang, Guo-Li ^{[2
]}

Teng, Ming-Yu ^{[2
]}

机构：

[1] Yunnan Normal Univ, Dept Lib, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 13期

关键词：

C-H ACTIVATION; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; ARYL HALIDES; FUNCTIONALIZATION; DERIVATIVES; TECHNOLOGY; EXTENSION; ANALOGS;

D O I：

10.1021/acs.joc.3c00344

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel three-component Pd/norbornene cooperative catalysiscascadedecarboxylative [2+2+2]/[2+2+3]cyclization of 4-iodoisoquinolin-1(2H)-ones and o-bromobenzoic acids or 8-bromo-1-naphthoicacid has been developed. The method affords a range of fused phenanthridinonesand hepta[1,2-c]isoquinolinones and displays uniqueregioselectivity and broad substrate scope. Palladium/norbornene (Pd/NBE)-catalyzedC-H activation and subsequent decarboxylative coupling reactionswere involved, and NBE acts as a building block for the constructionof rigid nonplanar molecular architectures.

引用

页码：8329 / 8344

页数：16

共 2 条

[1] Palladium-Catalyzed Cascade Cyclization of Alkene-Tethered Aryl Halides with o-Bromobenzoic Acids: Access to Diverse Fused Indolo[2,1-a]isoquinolines
Yang, Xiumei
Lu, Haiyan
Zhu, Xiaoming
Zhou, Liwei
Deng, Guobo
Yang, Yuan
Liang, Yun
ORGANIC LETTERS, 2019, 21 (18) : 7284 - 7288
[2] A palladium-catalyzed Heck/[4+1] decarboxylative cyclization cascade to access diverse heteropolycycles by using α-bromoacrylic acids as C1 insertion units
Zhang, Minghao
Zhou, Fengru
Xuchen, Xinyu
Zhou, Liwei
Deng, Guobo
Liang, Yun
Yang, Yuan
ORGANIC CHEMISTRY FRONTIERS, 2021, 8 (20) : 5687 - 5692

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