A genome-wide association study of antidepressant-induced mania

被引：3

作者：

Zai, Clement C. ^{[1
,2
,3
,4
,5
]}

Squassina, Alessio ^{[6
]}

Tiwari, Arun K. ^{[1
,2
]}

Pisanu, Claudia ^{[6
]}

Pinna, Marco ^{[7
,10
]}

Pinna, Federica ^{[7
,8
]}

Meloni, Anna ^{[6
]}

Paribello, Pasquale ^{[7
,8
]}

Carpiniello, Bernardo ^{[7
,8
]}

Tondo, Leonardo ^{[10
,11
]}

Frye, Mark A. ^{[12
]}

Biernacka, Joanna M. ^{[12
,13
]}

Coombes, Brandon J. ^{[13
]}

Kennedy, James L. ^{[1
,2
,3
]}

Manchia, Mirko ^{[7
,8
,9
,11
]}

机构：

[1] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Tanenbaum Ctr Pharmacogenet, Mol Brain Sci Dept, Toronto, ON, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[3] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[4] Univ Toronto, Lab Med & Pathobiol, Toronto, ON, Canada

[5] Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA USA

[6] Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy

[7] Univ Cagliari, Unit Psychiat, Dept Med Sci & Publ Hlth, I-09124 Cagliari, Italy

[8] Univ Hosp Agcy Cagliari, Unit Clin Psychiat, I-09124 Cagliari, Italy

[9] Dalhousie Univ, Dept Pharmacol, Halifax, NS B3H 4R2, Canada

[10] Lucio Bini Mood Disorders Ctr, Cagliari, Italy

[11] Harvard Med Sch, McLean Hosp, Boston, MA USA

[12] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA

[13] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2023年 / 127卷

关键词：

Antidepressant-induced mania; Genome-wide association study; Bipolar disorder; Pharmacogenetics; Depression; TREATMENT ENHANCEMENT PROGRAM; BIPOLAR DISORDER; HEXOSE-6-PHOSPHATE DEHYDROGENASE; BDNF GENE; SWITCH; RISK; METAANALYSIS; BIOMARKERS; MUTATIONS; FEATURES;

D O I：

10.1016/j.pnpbp.2023.110800

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antidepressant-induced mania (AIM) is a side effect of antidepressant treatment that is characterized by mania or hypomania after the start of medication. It is likely polygenic, but its genetic component remains largely unexplored. We aim to conduct the first genome-wide association study of AIM in 814 bipolar disorder patients of European ancestry. We report no significant findings from our single-marker or gene-based analyses. Our polygenic risk score analyses also did not yield significant results with bipolar disorder, antidepressant response, or lithium response. Our suggestive findings on the hypothalamic-pituitary-adrenal axis and the opioid system in AIM require independent replications.

引用

页数：6

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