Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review

被引:16
|
作者
Singh, Kuldeep [1 ]
Bhushan, Bharat [2 ]
Chanchal, Dilip Kumar [3 ]
Sharma, Satish Kumar [3 ]
Rani, Ketki [4 ]
Yadav, Manoj Kumar [5 ]
Porwal, Prateek [3 ]
Kumar, Shivendra [1 ]
Sharma, Ashwani [6 ]
Virmani, Tarun [6 ]
Kumar, Girish [6 ]
Noman, Abdullah Al [7 ]
机构
[1] Rajiv Acad Pharm, Dept Pharmaceut, Mathura, Uttar Pradesh, India
[2] GLA Univ Mathura, Inst Pharmaceut Res, Dept Pharmacol, Mathura, Uttar Pradesh, India
[3] Glocal Univ, Glocal Sch Pharm, Dept Pharmacognosy, Saharanpur, Uttar Pradesh, India
[4] SGT Univ, SGT Coll Pharm, Dept Chem, Gurugram, Haryana, India
[5] Dr Bhimrao Ambedkar Univ, Dept Pharmacol, Chhalesar Campus, Agra, Uttar Pradesh, India
[6] MVN Univ, Sch Pharmaceut Sci, Palwal 121105, Haryana, India
[7] BRAC Univ, Sch Pharm, Dhaka, Bangladesh
关键词
RECEPTOR-TYPE; 1; ENDOCANNABINOID SYSTEM; DOUBLE-BLIND; DISEASE; SEIZURES; ANXIETY; STRESS; SAFETY; TOLERABILITY; EXPRESSION;
D O I
10.1155/2023/8825358
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease, which present major healthcare concerns on a worldwide scale. Despite the lack of available therapies, CBD has been shown to possess a variety of pharmacological effects in preclinical and clinical studies, making it an intriguing competitor. This review brings together the most recent findings on the endocannabinoid and neurotransmitter systems, as well as anti-inflammatory pathways, that underlie CBD's modes of action. Synthesized efficacy and safety assessments for a range of neurological illnesses are included, covering human trials, in vitro studies, and animal models. The investigation includes how CBD could protect neurons, control neuroinflammation, fend off oxidative stress, and manage neuronal excitability. This study emphasizes existing clinical studies and future possibilities in CBD research, addressing research issues such as regulatory complications and contradicting results, and advocates for further investigation of therapeutic efficacy and ideal dose methodologies. By emphasizing CBD's potential to improve patient well-being, this investigation presents a revised viewpoint on its suitability as a therapeutic intervention for neurological illnesses.
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页数:17
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