Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain-states during resting-state activity

被引:4
|
作者
Alonso, Sonsoles [1 ,3 ]
Tyborowska, Anna [2 ,4 ,5 ]
Ikani, Nessa [4 ,6 ,7 ]
Mocking, Roel J. T. [8 ]
Figueroa, Caroline A. [9 ,10 ]
Schene, Aart H. [4 ,5 ]
Deco, Gustavo [11 ,12 ]
Kringelbach, Morten L. [13 ,14 ,15 ]
Cabral, Joana [16 ]
Ruhe, Henricus G. [4 ,5 ]
机构
[1] Aarhus Univ, Ctr Functionally Integrat Neurosci, Dept Clin Med, Aarhus, Denmark
[2] Radboud Univ Nijmegen, Behav Sci Inst, Dept Clin Psychol, Nijmegen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Cognit Neurosci Ctr, Dept Biomed Sci Cells & Syst, Groningen, Netherlands
[4] Radboud Univ Nijmegen Med Ctr, Dept Psychiat, Nijmegen, Netherlands
[5] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
[6] ProPersona Mental Hlth Care, Depress Expertise Ctr, Nijmegen, Netherlands
[7] Pro Persona Mental Hlth Care, Overwaal Ctr Expertise Anxiety Disorders, OCD & PTSD, Nijmegen, Netherlands
[8] Amsterdam UMC, Locat AMC, Dept Psychiat, Amsterdam, Netherlands
[9] Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands
[10] Univ Calif Berkeley, Sch Social Welf, Berkeley, CA 94720 USA
[11] Univ Pompeu Fabra, Ctr Brain & Cognit, Dept Informat & Commun Technol, Computat Neurosci Grp, Barcelona, Spain
[12] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain
[13] Univ Oxford, Linacre Coll, Ctr Eudaimonia & Human Flourishing, Oxford, England
[14] Aarhus Univ, Ctr Mus Brain, Aarhus, Denmark
[15] Univ Oxford, Dept Psychiat, Oxford, England
[16] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Braga, Portugal
关键词
dynamic functional connectivity; MDD; recurrence; resting-state fMRI; ANTERIOR CINGULATE CORTEX; LARGE-SCALE BRAIN; FUNCTIONAL CONNECTIVITY; DISORDER; NETWORKS; ROBUST; FMRI; DYSFUNCTION; CIRCUITRY; CONNECTOMICS;
D O I
10.1002/hbm.26475
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recurrence in major depressive disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting-state networks have been linked to MDD, but most approaches focus on stable (vs. dynamic) network characteristics. We investigated how the brain's dynamical repertoire changes after patients transition from remission to recurrence of a new depressive episode. Sixty two drug-free, MDD-patients with & GE;2 episodes underwent a baseline resting-state fMRI scan when in remission. Over 30-months follow-up, 11 patients with a recurrence and 17 matched-remitted MDD-patients without a recurrence underwent a second fMRI scan. Recurrent patterns of functional connectivity were characterized by applying Leading Eigenvector Dynamics Analysis (LEiDA). Differences between baseline and follow-up were identified for the 11 non-remitted patients, while data from the 17 matched-remitted patients was used as a validation dataset. After the transition into a depressive state, basal ganglia-anterior cingulate cortex (ACC) and visuo-attentional networks were detected significantly more often, whereas default mode network activity was found to have a longer duration. Additionally, the fMRI signal in the basal ganglia-ACC areas underlying the reward network, were significantly less synchronized with the rest of the brain after recurrence (compared to a state of remission). No significant changes were observed in the matched-remitted patients who were scanned twice while in remission. These findings characterize changes that may be associated with the transition from remission to recurrence and provide initial evidence of altered dynamical exploration of the brain's repertoire of functional networks when a recurrent depressive episode occurs. In major depressive disorder (MDD), a neural reconfiguration takes place after transitioning from a state of remission to a depressive episode. Dynamic measures of network connectivity in MDD patients indicate increased engagement of the reward and visuo-attentional networks, and longer duration of default mode network recruitment during a state of recurrence. Increased engagement of the reward network (basal ganglia-anterior cingulate cortex) during recurrence is due to a decoupling of this circuit from remaining neural activity.& DAG;image
引用
收藏
页码:5770 / 5783
页数:14
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