Effect of dienogest on serum anti-Mullerian hormone level after laparoscopic cystectomy of ovarian endometrioma

被引:5
|
作者
Weng, Shih-Shien [1 ]
Wang, Yeou-Lih [1 ]
Chuang, Fu-Ching [1 ]
Sun, Fang-Ju [2 ]
机构
[1] MacKay Mem Hosp, Dept Obstet & Gynecol, 92, Sect 2,Chung Shan North Rd, Taipei 10449, Taiwan
[2] MacKay Mem Hosp, Dept Med Res, Taipei, Taiwan
来源
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY | 2023年 / 62卷 / 04期
关键词
Anti-mullerian hormone; Dienogest; Endometrioma; Laparoscopy; WOMEN;
D O I
10.1016/j.tjog.2023.02.004
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: This comparative study aimed to evaluate the effect of postoperative dienogest treatment on serum anti-Mullerian hormone (AMH) levels in patients undergoing laparoscopic cystectomy of ovarian endometriomas. Materials and methods: A total of 71 patients with ovarian endometriomas treated at our department were enrolled. After surgery, 54 patients received oral dienogest 2 mg daily continuously for 6 months (dienogest group). The other 17 patients did not receive postoperative medical treatment (control group). Serum AMH levels were measured before surgery, at 3-month period after surgery, and at the end of 6month follow-up period. Serial changes of AMH levels were compared between the two groups. Results: The age, endometrioma size, and serum AMH level before surgery were comparable between the dienogest group and the control group. The AMH levels decreased significantly at 3-month period after surgery in the dienogest group (a decrease of 65.5%; p < 0.001) and the control group (a decrease of 64.8%; p = 0.018). The AMH levels increased gradually from the nadir at 3-month period after surgery and recovered partially at the end of 6-month follow-up period in both groups. There were no statistically significant differences in the rate of reduction of serum AMH levels between the two groups (p = 0.707). Conclusion: Laparoscopic cystectomy of ovarian endometrioma causes a significant decrease in serum AMH levels. The rates of reduction of AMH levels are similar regardless of dienogest treatment. Postoperative dienogest treatment for 6 months has no rescue effect on serum AMH levels in these patients. & COPY; 2023 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页码:521 / 524
页数:4
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