Associations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults

被引:4
|
作者
Jia, Hao [1 ,2 ]
Bao, Peng [3 ]
Yao, Shi [4 ]
Zhang, Xi [1 ]
Mu, Jian-Jun [1 ,2 ]
Hu, Gui-Lin [1 ]
Du, Ming-Fei [1 ]
Chu, Chao [1 ,2 ]
Zhang, Xiao-Yu [5 ]
Wang, Lan [6 ]
Liao, Yue-Yuan [1 ,2 ]
Wang, Dan [1 ,2 ]
Ma, Qiong [1 ,2 ]
Yan, Yu [1 ,2 ]
Niu, Ze-Jiaxin [1 ]
Gao, Wei-Hua [7 ]
Li, Hao [5 ]
Wu, Guan-Ji [8 ]
Chang, John [9 ]
Wang, Yang [1 ,2 ]
机构
[1] Xi An Jiao Tong Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Xian, Peoples R China
[2] Key Lab Mol Cardiol Shaanxi Prov, Xian, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Practice, Shanghai, Peoples R China
[4] Xi An Jiao Tong Univ, Affiliated Hosp 2, Natl & Local Joint Engn Res Ctr Biodiag & Biothera, Xian, Peoples R China
[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Crit Care Med, Xian, Peoples R China
[6] Xian Int Med Ctr Hosp, Dept Cardiol, Xian, Peoples R China
[7] Xian 1 Hosp, Dept Cardiol, Xian, Peoples R China
[8] Xi An Jiao Tong Univ, Xian Cent Hosp, Dept Cardiol, Xian, Peoples R China
[9] Yale Univ, Sch Med, Dept Med, New Haven, CT 06520 USA
基金
中国国家自然科学基金;
关键词
SGLT2; Salt sensitivity; Blood pressure; Gene polymorphism; VARIANTS; PREDISPOSITION; DAPAGLIFLOZIN; INHIBITORS; REDUCTION;
D O I
10.1038/s41440-023-01301-2
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lowers blood pressure (BP) and exert a salutary effect on the salt sensitivity of BP. This study aimed to examine the associations of SGLT2 genetic variants with salt sensitivity, longitudinal BP changes and the risk of incident hypertension in Baoji Salt-Sensitive Study. A total of 514 participants were recruited when the cohort was established in 2004, and 333 participants received a dietary intervention that consisted of a 3-day usual diet followed sequentially by a 7-day low-salt diet and a 7-day high-salt diet. The cohort was then followed up for 14 years to evaluate the longitudinal BP changes and development of hypertension. We found that SGLT2 SNP rs3813007 was significantly associated with the systolic BP (SBP) responses to the low-salt diet. Over the 14 years of follow-up, SNPs rs3116149 and rs3813008 were significantly associated with the longitudinal SBP changes, and SNPs rs3116149, rs3813008, rs3813007 in SGLT2 were significantly associated with incidence of hypertension. Furthermore, gene-based analyses revealed that SGLT2 was significantly associated with hypertension incidence. Our study suggests that SGLT2 genetic polymorphisms may be involved in salt sensitivity and development of hypertension.
引用
收藏
页码:1795 / 1803
页数:9
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