Impact of Renal Congestion in Patients With Secondary Mitral Regurgitation After Mitral Transcatheter Edge-to-Edge Repair

被引:3
|
作者
Kuwata, Shingo [1 ,3 ]
Izumo, Masaki [1 ]
Okuno, Taishi [1 ]
Shiokawa, Noriko [2 ]
Sato, Yukio [1 ]
Koga, Masashi [1 ]
Okuyama, Kazuaki [1 ]
Tanabe, Yasuhiro [1 ]
Harada, Tomoo [1 ]
Ishibashi, Yuki [1 ]
Akashi, Yoshihiro J. [1 ]
机构
[1] St Marianna Univ, Sch Med, Dept Cardiol, Kawasaki, Japan
[2] St Marianna Univ Hosp, Diagnost Med Sonog, Kawasaki, Japan
[3] St Marianna Univ, Sch Med, Dept Cardiol, 2-16-1 Sugao,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan
关键词
MitraClip; Renal congestion; Transcatheter mitral valve repair; DOPPLER ULTRASONOGRAPHY; CARDIORENAL SYNDROME; VENOUS-PRESSURE; HEART;
D O I
10.1253/circj.CJ-23-0240
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Renal congestion is a potential prognostic factor in patients with heart failure and recently, assessment has become possible with intrarenal Doppler ultrasonography (IRD). The association between renal congestion assessed by IRD and outcomes after mitral transcatheter edge -to -edge repair (TEER) is unknown, so we aimed to clarify renal congestion and its prognostic implications in patients with mitral regurgitation (MR) who underwent TEER using MitraClip system. Methods and Results: Patients with secondary MR who underwent TEER and were assessed for intrarenal venous flow (IRVF) by IRD were classified according to their IRVF pattern as continuous or discontinuous. Of the 105 patients included, 78 patients (74%) formed the continuous group and 27 (26%) were the discontinuous group. Kaplan -Meier analysis revealed significant prognostic power of the IRVF pattern for predicting the composite outcome of all -cause death and heart failure rehospitalization (log -rank P=0.0257). On multivariate Cox regression analysis, the composite endpoint was independently associated with the discontinuous IRVF pattern (hazard ratio, 3.240; 95% confidence interval, 1.300-8.076; P=0.012) adjusted using inverse probability of treatment weighting. Conclusions: IRVF patterns strongly correlated with clinical outcomes without changes in renal function. Thus, they may be useful for risk stratification after mitral TEER for patients with secondary MR.
引用
收藏
页码:510 / 516
页数:10
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