Rhodium-catalyzed enantioselective annulation of N-phenoxyacetamides with 1,3-dienes

被引：6
|
作者：
Yang, Hui [1 ]
Yang, Zi-Qi [1 ]
Zhang, Su-Zhen [1 ]
Zhang, Wen-Wen [1 ]
Gu, Qing [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2023年 / 66卷 / 10期
基金：
中国国家自然科学基金;
关键词：
asymmetric catalysis; C-H functionalization; rhodium catalysis; chiral dihydrobenzofuran; C-H FUNCTIONALIZATION; ASYMMETRIC HYDROGENATION; BOND FUNCTIONALIZATION; ACTIVATION; RH; DERIVATIVES; BENZOFURAN; ALKYLATION; AMIDATION; COMPLEXES;
D O I：
10.1007/s11426-023-1637-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chiral dihydrobenzofuran is a valuable synthetic fragment in both medicinal and organic chemistry. Efficient rhodium(III)-catalyzed chemoselective and enantioselective C-H functionalization/[3+2] annulation of N-phenoxyacetamides with 1,3-dienes is reported. In the presence of 5 mol% CpRh complex, various chiral dihydrobenzofurans were synthesized in up to 79% yield and 98% ee. This reaction proceeds under mild conditions with excellent functional group compatibility.
引用
收藏
页码：2842 / 2846
页数：5
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