Bifidobacterium bifidum E3 Combined with Bifidobacterium longum subsp. infantis E4 Improves LPS-Induced Intestinal Injury by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways In Vivo

被引:18
|
作者
Yue, Yingxue [1 ]
Wang, Yuqi [2 ]
Xie, Qinggang [1 ,3 ]
Lv, Xiuli [1 ]
Zhou, Linyi [4 ]
Smith, Etareri Evivie [1 ,5 ,6 ]
Cao, Ting [1 ]
Zhang, Yifan [1 ]
Li, Bailiang [1 ]
Huo, Guicheng [1 ]
Ma, Weiwei [7 ]
机构
[1] Northeast Agr Univ, Food Coll, Harbin 150030, Peoples R China
[2] Heilongjiang Jinxiang Biochem Co Ltd, Harbin 150030, Peoples R China
[3] Heilongjiang Feihe Dairy Co Ltd, Qiqihar 164800, Peoples R China
[4] Beijing Technol & Business Univ BTBU, China Sch Food & Hlth, Beijing 100048, Peoples R China
[5] Univ Benin, Fac Agr, Dept Anim Sci, Benin 300001, Nigeria
[6] Univ Benin, Fac Agr, Dept Food Sci & Human Nutr, Benin 300001, Nigeria
[7] Heilongjiang Univ Chinese Med, Coll Pharm, Harbin 150000, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Bifidobacterium; intestinal immunity; inflammation; NF kappa B/MAPK signaling pathway; gut microbiota; metabonomics; NF-KAPPA-B; INFLAMMATORY-BOWEL-DISEASE; CHAIN FATTY-ACIDS; BARRIER FUNCTION; GENE-EXPRESSION; MUCOSAL BARRIER; CELLS; LIPOPOLYSACCHARIDE; COLITIS; MICE;
D O I
10.1021/acs.jafc.3c00421
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Changes in the functions of the intestinal barrier occur in parallel with the development of sepsis. The protection by Bifidobacterium strains (BB, BL, BB12, and BLBB) was evaluated in mice injected with lipopolysaccharide (LPS). The results revealed an increase in the ratio of ileal villus length to crypt depth in the BLBB group compared with that in the LPS group, as were the number of IgA(+) plasma, CD4(+)/CD8(+) T, and dendritic cells. The levels of diamine oxidase (DAO) and D-lactic acid in the serum were lessened in the BLBB group after LPS injection compared with that in the LPS group. In addition, the BLBB group exhibited an increased expression level of tight junction proteins (zonula occludens-1, occludin, and claudin-1), mucin (MUC2) mRNA, reduced NF kappa/MAPK signaling pathways, and decreased expression levels of inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha). The BLBB group enriched the relative abundance of Muribaculaceae, Lachnospiraceae_NK4A136_group, Clostridia_Ucg-014, and Alistipes, resulting in an increase in strains producing short-chain fatty acids. Furthermore, the BLBB group leads to higher levels of deoxycholic acid and biosynthesized linoleate. This study suggested that the BLBB group could enhance the capacity of the intestinal barrier and intestinal mucosal immunity, reduce intestinal inflammation, and improve the composition of gut microbiota. Bifidobacterium bifidum E3 combined with Bifidobacterium longum subsp. infantis E4 may thus serve as a probiotic against the intestinal injury caused by LPS.
引用
收藏
页码:8915 / 8930
页数:16
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