Base-Catalyzed Synthesis of N-Aryl Thioacetamides from Multicomponent Reaction of Phenylacetylenes, Sulfur and Anilines

被引：3

作者：

Hang Nguyen, Minh ^{[1
]}

Sam Nguyen, Hai ^{[1
]}

Anh Nguyen, Le ^{[2
,3
]}

Ngoc Nguyen, Bich ^{[1
,4
]}

Thuong Cao, Hai ^{[4
]}

Hung Mac, Dinh ^{[1
]}

Binh Nguyen, Thanh ^{[5
]}

机构：

[1] VNU Univ Sci, Vietnam Natl Univ Hanoi, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam

[2] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[3] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[4] Le Quy Don Tech Univ, 236 Hoang Quoc Viet, Cau Giay, Ha Noi, Vietnam

[5] Univ Paris Saclay, Univ Paris Sud, CNRS UPR 2301, Inst Chim Subst Nat, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 10期

关键词：

elemental sulfur; thioamide; multicomponent reaction; thioketene; atom economy; ONE-POT SYNTHESIS; AMINES ACCESS; THIOAMIDES; EFFICIENT; AMIDES;

D O I：

10.1002/ejoc.202301319

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a base catalyst (20 mol %) such as DBU, DABCO or Na2S & sdot; 3H(2)O/N-methylpyrrolidone, phenylacetylenes were found to efficiently undergo sulfurative amination with elemental sulfur and anilines under neat conditions, leading to N-aryl thioamides with complete atom efficiency.

引用

页数：4

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