Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act

被引：7

作者：

Motter, Jennifer D. ^{[1
]}

Hussain, Sarah ^{[2
]}

Brown, Diane M. ^{[2
]}

Florman, Sander ^{[3
]}

Rana, Meenakshi M. ^{[3
]}

Friedman-Moraco, Rachel ^{[4
]}

Gilbert, Alexander J. ^{[5
]}

Stock, Peter ^{[6
]}

Mehta, Shikha ^{[7
]}

Mehta, Sapna A. ^{[8
]}

Stosor, Valentina ^{[9
,10
]}

Elias, Nahel ^{[11
]}

Pereira, Marcus R. ^{[12
]}

Haidar, Ghady ^{[13
]}

Malinis, Maricar ^{[14
]}

Morris, Michele I. ^{[15
]}

Hand, Jonathan ^{[16
]}

Aslam, Saima ^{[17
]}

Schaenman, Joanna M. ^{[18
]}

Baddley, John ^{[19
]}

Small, Catherine B. ^{[20
]}

Wojciechowski, David ^{[21
]}

Santos, Carlos A. Q. ^{[22
]}

Blumberg, Emily A. ^{[23
]}

Odim, Jonah ^{[24
]}

Apewokin, Senu K. ^{[25
]}

Giorgakis, Emmanouil ^{[26
]}

Bowring, Mary Grace ^{[27
]}

Werbel, William A. ^{[2
]}

Desai, Niraj M. ^{[27
]}

Tobian, Aaron A. R. ^{[2
]}

Segev, Dorry L. ^{[1
,28
,29
]}

Massie, Allan B. ^{[1
,28
]}

Durand, Christine M. ^{[2
,30
]}

机构：

[1] NYU Grossman Sch Med, Dept Surg, New York, NY USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA

[3] Icahn Sch Med Mt Sinai, Dept Med, New York, NY USA

[4] Emory Univ, Dept Med, Atlanta, GA USA

[5] Medstar Georgetown, Dept Med, Washington, DC USA

[6] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[7] Univ Alabama Birmingham, Dept Med, Birmingham, AL USA

[8] NYU, Grossman Sch Med, Dept Med, New York, NY USA

[9] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL USA

[10] Northwestern Univ, Div Organ Transplantat, Feinberg Sch Med, Chicago, IL USA

[11] Massachusetts Gen Hosp, Dept Surg, Boston, MA USA

[12] Columbia Univ, Irving Med Ctr, Dept Med, New York, NY USA

[13] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[14] Yale Sch Med, Dept Med, New Haven, CT USA

[15] Univ Miami, Miller Sch Med, Dept Med, Miami, FL USA

[16] Ochsner Hlth, Dept Med, New Orleans, LA USA

[17] Univ Calif San Diego, Dept Med, La Jolla, CA USA

[18] UCLA, Dept Med, Div Infect Dis, David Geffen Sch Med, Los Angeles, CA USA

[19] Univ Maryland, Sch Med, Dept Med, Baltimore, MD USA

[20] Weill Cornell Med, Dept Med, Div Infect Dis, New York, NY USA

[21] UT Southwestern Med Ctr, Dept Med, Dallas, TX USA

[22] Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USA

[23] Hosp Univ Penn, Dept Med, Philadelphia, PA USA

[24] NIAID, NIH, Div Allergy Immunol & Transplantat, Bethesda, MD USA

[25] Univ Cincinnati, Dept Med, Med Ctr, Cincinnati, OH USA

[26] Univ Arkansas Med Sci, Dept Surg, Little Rock, AR USA

[27] Johns Hopkins Univ, Dept Surg, Sch Med, Baltimore, MD USA

[28] NYU, Grossman Sch Med, Dept Populat Hlth, New York, NY USA

[29] Sci Registry Transplant Recipients, Minneapolis, MN USA

[30] Johns Hopkins Sch Med, Dept Med, 2000 Monument St, Baltimore, MD 21206 USA

来源：

TRANSPLANTATION | 2024年 / 108卷 / 03期

关键词：

D O I：

10.1097/TP.0000000000004857

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background.Kidney transplant (KT) candidates with HIV face higher mortality on the waitlist compared with candidates without HIV. Because the HIV Organ Policy Equity (HOPE) Act has expanded the donor pool to allow donors with HIV (D+), it is crucial to understand whether this has impacted transplant rates for this population. Methods.Using a linkage between the HOPE in Action trial (NCT03500315) and Scientific Registry of Transplant Recipients, we identified 324 candidates listed for D+ kidneys (HOPE) compared with 46 025 candidates not listed for D+ kidneys (non-HOPE) at the same centers between April 26, 2018, and May 24, 2022. We characterized KT rate, KT type (D+, false-positive [FP; donor with false-positive HIV testing], D- [donor without HIV], living donor [LD]) and quantified the association between HOPE enrollment and KT rate using multivariable Cox regression with center-level clustering; HOPE was a time-varying exposure. Results.HOPE candidates were more likely male individuals (79% versus 62%), Black (73% versus 35%), and publicly insured (71% versus 52%; P < 0.001). Within 4.5 y, 70% of HOPE candidates received a KT (41% D+, 34% D-, 20% FP, 4% LD) versus 43% of non-HOPE candidates (74% D-, 26% LD). Conversely, 22% of HOPE candidates versus 39% of non-HOPE candidates died or were removed from the waitlist. Median KT wait time was 10.3 mo for HOPE versus 60.8 mo for non-HOPE candidates (P < 0.001). After adjustment, HOPE candidates had a 3.30-fold higher KT rate (adjusted hazard ratio = 3.30, 95% confidence interval, 2.14-5.10; P < 0.001). Conclusions.Listing for D+ kidneys within HOPE trials was associated with a higher KT rate and shorter wait time, supporting the expansion of this practice for candidates with HIV.

引用

页码：759 / 767

页数：9

共 7 条

[1] Wait Time Advantage for Transplant Candidates with HIV Who Accept Kidneys from Donors with HIV
Motter, J. D.
Hussain, S.
Florman, S.
Rana, M.
Friedman-Moraco, R.
Gilbert, A.
Stock, P.
Mehta, S.
Mehta, S. A.
Stosor, V.
Elias, N.
Pereira, M.
Haidar, G.
Malinis, M.
Morris, M.
Hand, J.
Aslam, S.
Schaenman, J.
Baddley, J.
Small, C.
Wojciechowski, D.
Hollinger, E. F.
Blumberg, E.
Odim, J.
Apewokin, S.
Giorgakis, E.
Tobian, A.
Segev, D.
Massie, A. B.
Durand, C. M.
AMERICAN JOURNAL OF TRANSPLANTATION, 2023, 23 (06) : S571 - S572
[2] Expanding Hope Act Experience Criteria for Transplantation from Donors with HIV to Recipients with HIV
Bowring, M.
Ruck, J.
Bryski, M.
Werbel, W.
Tobian, A.
Massie, A.
Segev, D.
Durand, C.
AMERICAN JOURNAL OF TRANSPLANTATION, 2023, 23 (06) : S473 - S474
[3] Willingness to accept and beliefs regarding organs from HIV-infected donors: a multi-center surveyof HIV plus transplant candidates
Rasmussen, Sarah
Seaman, Shanti
Nguyen, Anh Q.
Bowring, Mary Grace
You, Susan
Halpern, Samantha
Brown, Diane
Massie, Allan
Tobian, Aaron
Henderson, Macey
Fletcher, Faith
Smith, Burke
Prakash, Katya
Aslam, Saima
Lee, Dong
Trinh, Sonya
Kirchner, Varvara
Haidar, Ghady
Hughes, Kailey
Malinis, Maricar
Segev, Dorry
Sugarman, Jeremy
Chao, Ada
Durand, Christine
Gorupati, Nishita
AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 : 61 - 61
[4] Willingness to Accept and Beliefs Regarding Organs from HIV-Infected Donors: A Multi-Center Survey of Transplant Candidates Living with HIV
Rasmussen, S.
Seaman, S.
Bowring, M.
Brown, D.
Massie, A.
Tobian, A.
Henderson, M.
Fletcher, F.
Smith, B.
Chao, A.
Gorupati, N.
Prakash, K.
Aslam, S.
Lee, D.
Trinh, S.
Kirchner, V.
Pruett, T.
Haidar, G.
Hughes, K.
Malinis, M.
Segev, D.
Sugarman, J.
Durand, C.
AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 : 376 - 377
[5] Abdominal Transplantation from Hcv-Viremic and Hcv/Hiv Co-Infected Donors to Recipients with Hiv Under the Hope Act
Aslam, S.
Hussain, S.
Haydel, B.
Florman, S.
Gilbert, A.
Pereira, M.
Elias, N.
Mekeel, K.
Schnickel, G.
Shah, M.
Ajmera, V.
Massie, A. B.
Segev, D.
Segev, D.
Durand, C.
Rana, M.
AMERICAN JOURNAL OF TRANSPLANTATION, 2023, 23 (06) : S396 - S397
[6] Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act
Durand, Christine M.
Halpern, Samantha E.
Bowring, Mary G.
Bismut, Gilad A.
Kusemiju, Oyinkansola T.
Doby, Brianna
Fernandez, Reinaldo E.
Kirby, Charles S.
Ostrander, Darin
Stock, Peter G.
Mehta, Shikha
Turgeon, Nicole A.
Wojciechowski, David
Huprikar, Shirish
Florman, Sander
Ottmann, Shane
Desai, Niraj M.
Cameron, Andrew
Massie, Allan B.
Tobian, Aaron A. R.
Redd, Andrew D.
Segev, Dorry L.
AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 (10) : 2579 - 2586
[7] The incidence of hbsag, anti-HCV, anti-HIV and Treponema Pallidum anti bodies in blood donors who donate blood for the first time from the eastern part of republic of macedonia
Vitlarova, J.
Kamcev, N.
Velickova, N.
Kamceva, G.
Dejanova, V
VOX SANGUINIS, 2008, 95 : 272 - 273

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