Ocular Sarcoidosis and Autoimmune Polyglandular Syndrome Type 2: A Case Report

被引:2
|
作者
Pinheiro, Rosa Lomelino [1 ]
Pinheiro, Sara Lomelino [2 ]
Silva, Tiago Nunes [2 ,3 ,4 ]
Canha, Catarina [5 ]
Dias Ferrao Fonseca, Maria Cristina [1 ,6 ]
Mateus Barreiros Proenca, Rui Daniel [1 ,6 ]
机构
[1] Ctr Hosp & Univ Coimbra, Ctr Responsabilidade Integrad Oftalmol, P-3000075 Coimbra, Portugal
[2] Inst Portugues Oncol Francisco Gentil, Dept Endocrinol, Lisbon, Portugal
[3] Univ Nova Lisboa, Nova Med Sch, Lisbon, Portugal
[4] Inst Portugues Oncol Francisco Gentil, Mol Pathobiol Res Unit UIPM, Lisbon, Portugal
[5] Ctr Hosp & Univ Coimbra, Dept Internal Med, Coimbra, Portugal
[6] Univ Coimbra, Clin Acad Ctr Coimbra, Fac Med, Coimbra, Portugal
关键词
Addison's disease; autoimmune polyglandular syndrome; ocular sarcoidosis; sarcoidosis; uveitis; DISEASE;
D O I
10.1080/09273948.2022.2122513
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose to describe a clinical case of ocular sarcoidosis in a patient with Autoimmune Polyglandular Syndrome Type 2 (APS-2). Methods an 86-year-old female diagnosed with APS-2 was referred to our uveitis department with rapid visual loss in her left eye during a 3-month period. Her best-corrected visual acuity (BCVA) was counting fingers in her left eye (OS) and 20/40 in her right eye (OD). Slit-lamp biomicroscopy was unremarkable OD but revealed granulomatous keratic precipitates OS. Fundoscopy revealed bilateral optic disc oedema and +2 and 4+ vitritis (SUN classification) in her OD and OS, respectively. Results the patient underwent chest X-Ray which revealed bilateral hilar lymphadenopathy and fibrosis. On high-resolution computed tomography of the lungs, ground-glass opacities were visible, and a diagnosis of ocular sarcoidosis was presumed. After exclusion of infectious diseases, the patient was treated with methotrexate and oral corticosteroids and there was substantial improvement of the optic nerve oedema and vitritis. At the most recent visit, 2 years later, OS BCVA was 20/50. Conclusion There may be an association between ocular sarcoidosis and APS or other autoimmune disorders.
引用
收藏
页码:137 / 140
页数:4
相关论文
共 50 条
  • [21] Polyglandular Syndrome Type 1 Autoimmune: Report of an Unusual Family Case
    Frana Rodrigues, F.
    Arruda Franco, A.
    Trindade Manfredi, T.
    Constancia da Cunha Urtiga, L.
    Alencar Barreira, P.
    de Paula Castro, P. B.
    Diniz Rodrigues, M.
    Reis de Sa, A. M.
    Spinola e Castro, A. M.
    Siviero Miachon, A. A.
    Esgrignoli Garcia, F.
    HORMONE RESEARCH IN PAEDIATRICS, 2016, 86 : 54 - 54
  • [22] Neurotrophic keratitis in autoimmune polyglandular syndrome type 1: a case report
    Po-Ying Wu
    Huai-Wen Chang
    Wei-Li Chen
    BMC Ophthalmology, 21
  • [23] A case of polyglandular autoimmune syndrome type II
    Misakian, AL
    Tyrrell, JB
    Schlegel, A
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2005, 20 : 221 - 221
  • [24] Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report
    Inaba, Hidefumi
    Ariyasu, Hiroyuki
    Iwakura, Hiroshi
    Kurimoto, Chiaki
    Ueda, Yoko
    Uraki, Shinsuke
    Takeshima, Ken
    Furukawa, Yasushi
    Morita, Shuhei
    Nakayama, Yoshiaki
    Ohashi, Takuya
    Ito, Hidefumi
    Nishimura, Yoshiharu
    Akamizu, Takashi
    BMC ENDOCRINE DISORDERS, 2020, 20 (01)
  • [25] Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report
    Hidefumi Inaba
    Hiroyuki Ariyasu
    Hiroshi Iwakura
    Chiaki Kurimoto
    Yoko Ueda
    Shinsuke Uraki
    Ken Takeshima
    Yasushi Furukawa
    Shuhei Morita
    Yoshiaki Nakayama
    Takuya Ohashi
    Hidefumi Ito
    Yoshiharu Nishimura
    Takashi Akamizu
    BMC Endocrine Disorders, 20
  • [26] POLYGLANDULAR AUTOIMMUNE SYNDROME, TYPE-2
    LEOR, J
    LEVARTOWSKY, D
    SHARON, C
    SOUTHERN MEDICAL JOURNAL, 1989, 82 (03) : 374 - 376
  • [27] Autoimmune Hepatitis as a Part of Polyglandular Autoimmune Syndrome Type II: Case Report and Literature Review
    Patel, Trushar
    Nystrom, Jacquelyn
    Pyrsopoulos, Nikolaos
    DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (03) : 861 - 864
  • [28] Late Diagnosed Type II Autoimmune Polyglandular Failure Syndrome: A Case Report
    Evran, Mehtap
    Tetiker, Tamer
    Sert, Murat
    TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2014, 18 (01) : 13 - 16
  • [29] Autoimmune Hepatitis as a Part of Polyglandular Autoimmune Syndrome Type II: Case Report and Literature Review
    Trushar Patel
    Jacquelyn Nystrom
    Nikolaos Pyrsopoulos
    Digestive Diseases and Sciences, 2010, 55 : 861 - 864
  • [30] INFLAMMATORY MYOPATHY ASSOCIATED WITH TYPE II POLYGLANDULAR AUTOIMMUNE SYNDROME: A CASE REPORT
    Maheswaranathan, M.
    Basco, W.
    Ruth, N.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2016, 64 (02) : 590 - 590