Distribution of Multidrug-Resistant Invasive Serotypes of Streptococcus pneumoniae during the Period 2007-2021 in Madrid, Spain

被引:2
|
作者
de Miguel, Sara [1 ,2 ,3 ,4 ]
Perez-Abeledo, Marta [5 ]
Ramos, Belen [5 ]
Garcia, Luis [1 ]
Arce, Araceli [1 ]
Martinez-Arce, Rodrigo [5 ]
Yuste, Jose [3 ,6 ]
Sanz, Juan Carlos [5 ,7 ]
机构
[1] Reg Minist Hlth Madrid, Epidemiol Dept, Directorate Gen Publ Hlth, Madrid 28002, Spain
[2] Univ Hosp 12 Octubre, Dept Prevent Med, Madrid 28041, Spain
[3] CIBER Resp Dis CIBERES, Madrid 28029, Spain
[4] Univ Alcala, Dept Epidemiol & Salud Publ Epidemiol Enfermedade, Madrid 28881, Spain
[5] Reg Minist Hlth Madrid, Clin Microbiol Unit, Publ Hlth Reg Lab Community Madrid, Directorate Gen Publ Hlth, Madrid 28055, Spain
[6] Inst Salud Carlos III, Spanish Pneumococcal Reference Lab, Natl Ctr Microbiol, Madrid 28222, Spain
[7] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid 28029, Spain
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 02期
关键词
Streptococcus pneumoniae; serotypes; multidrug-resistance; PCV13; penicillin; erythromycin; levofloxacin; PNEUMOCOCCAL DISEASE; CONJUGATE VACCINES; NON-SUSCEPTIBILITY; UNITED-STATES; MECHANISMS; PREVALENCE; EMERGENCE; OUTBREAK; CHILDREN; TRENDS;
D O I
10.3390/antibiotics12020342
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
After the systematic use of conjugate vaccines, the invasive pneumococcal disease (IPD) was included into the Madrid Notifiable Diseases Surveillance System through an Epidemiological Surveillance Network. Furthermore, Streptococcus pneumoniae was included in the Spanish Plan of Antibiotic Resistance. The aim of this study was to analyse the multidrug-resistant (MDR) phenotype distribution among invasive strains of Streptococcus pneumoniae isolated during 2007-2021 from usually sterile clinical samples in Madrid, Spain. A total number of 7133 invasive pneumococcal isolates were studied during the period from February 2007 to December 2021. Serotyping was characterised using the Pneumotest-Latex and by the Quellung reaction. Antibiotic susceptibility testing to penicillin (PEN), erythromycin (ERY), and levofloxacin (LVX) was performed using the E-test according to the EUCAST guidelines and breakpoints. Combination of non-susceptibility to PEN at standard dosing regimen (PNSSDR), resistance to ERY (ERYR) and to LVX (LVXR) was considered to be multidrug-resistant at standard dosing regimen of penicillin (MRPSDR), whereas the combination of resistance to PEN (PENR), ERYR, and LVXR was considered multidrug-resistant (MDR). The number of MDRPSDR and or MDR strains in the entire population (n = 7133) during the complete period (2007-2021) were 51 (0.7%) and 6 (0.1%), respectively. All MDRPSDR and/or MDR strains belonged to nine serotypes: 19A (n = 13), 15A (n = 12), 9V (n = 12), 14 (n = 7), 24F (n = 3), 15F (n = 1), 19F (n = 1), 6B (n = 1) and 6C (n = 1). Only two serotypes (9V and 19A) were found among MDR strains, and most of them (5/6) belonged to serotype 9V. Only 12.4% of the strains typified as serotype 9V were MDRPSDR and only 5.2% as MDR. The levels of pneumococcal MDRPSDR and/or MDR in this study were low and all six MDR strains were isolated between 2014 and 2018. These results reinforce the importance of monitoring the evolution of non-susceptible serotypes including those with MDR in the coming years, especially after the introduction of new conjugate vaccines of a broader spectrum.
引用
收藏
页数:8
相关论文
共 28 条
  • [1] Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of Streptococcus pneumoniae during 2007-2021 in Madrid, Spain
    de Miguel, Sara
    Perez-Abeledo, Marta
    Ramos, Belen
    Garcia, Luis
    Arce, Araceli
    Martinez-Arce, Rodrigo
    Yuste, Jose
    Sanz, Juan Carlos
    ANTIBIOTICS-BASEL, 2023, 12 (02):
  • [2] Clonal Spread of Levofloxacin-Resistant Streptococcus pneumoniae Invasive Isolates in Madrid, Spain, 2007 to 2009
    Rodriguez-Avial, Iciar
    Ramos, Belen
    Rios, Esther
    Cercenado, Emilia
    Ordobas, Maria
    Carlos Sanz, Juan
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (05) : 2469 - 2471
  • [3] Temporal progression of the distribution of Streptococcus pneumoniae serotypes causing invasive pneumococcal disease in Galicia (Spain) and its relationship with resistance to antibiotics (period 2011-2021)
    Losada-Castillo, Isabel
    Santiago-Perez, Isolina
    Juiz-Gonzalez, Pedro Miguel
    Mendez-Lage, Susana
    Purrinos-Hermida, Maria Jesus
    Malvar, Alberto
    Agulla-Budino, Jose Andres
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2024, 42 (04): : 179 - 186
  • [4] Temporal Trends of Invasive Streptococcus pneumoniae Serotypes and Antimicrobial Resistance Patterns in Spain from 1979 to 2007
    Fenoll, A.
    Granizo, J. J.
    Aguilar, L.
    Gimenez, M. J.
    Aragoneses-Fenoll, L.
    Hanquet, G.
    Casal, J.
    Tarrago, D.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (04) : 1012 - 1020
  • [5] Multidrug-resistant Streptococcus pneumoniae causing invasive pneumococcal disease isolated from a paediatric patient
    Arushothy, Revathy
    Ramasamy, Hema
    Hashim, Rohaidah
    Raj, Santhana A. S.
    Amran, Fairuz
    Samsuddin, Nazirah
    Ahmad, Norazah
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 90 : 219 - 222
  • [6] Streptococcus pneumoniae serotypes with meningeal tropism in cases of invasive pneumococcal disease. Community of Madrid, 2007-2018
    Carlos Sanz, Juan
    de Miguel, Sara
    Ordobas, Maria
    Garcia Comas, Luis
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2020, 38 (08): : 371 - 374
  • [7] Spread of Streptococcus pneumoniae Serotype 8-ST63 Multidrug-Resistant Recombinant Clone, Spain
    Ardanuy, Carmen
    de La Campa, Adela G.
    Garcia, Ernesto
    Fenoll, Asuncion
    Calatayud, Laura
    Cercenado, Emilia
    Perez-Trallero, Emilio
    Bouza, Emilio
    Linares, Josefina
    EMERGING INFECTIOUS DISEASES, 2014, 20 (11) : 1848 - 1856
  • [8] Multidrug-Resistant Hypervirulent Group B Streptococcus in Neonatal Invasive Infections, France, 2007-2019
    Plainvert, Celine
    Hays, Constantin
    Touak, Gerald
    Joubrel-Guyot, Caroline
    Dmytruk, Nicolas
    Frigo, Amandine
    Poyart, Claire
    Tazi, Asmaa
    EMERGING INFECTIOUS DISEASES, 2020, 26 (11) : 2721 - 2724
  • [9] Evolution of the distribution of Streptococcus pneumoniae serotypes isolated in pleural fluid in the Madrid Autonomous Community between the years 2007-2018
    Carlos Sanz, Juan
    de Miguel, Sara
    Ordobas, Maria
    Garcia Comas, Luis
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2021, 39 (01): : 25 - 28
  • [10] Carriage of multidrug-resistant Streptococcus pneumoniae and impact of chemoprophylaxis during an outbreak of meningitis at a day care center
    Craig, AS
    Erwin, PC
    Schaffner, W
    Elliott, JA
    Moore, WL
    Ussery, XT
    Patterson, L
    Dake, AD
    Hannah, SG
    Butler, JC
    CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) : 1257 - 1264