A delve into the pharmacological targets and biological mechanisms of Paederia foetida Linn.: a rather invaluable traditional medicinal plant

被引:10
|
作者
Sarma, Mrinal Kashyap [1 ]
Saha, Dipankar [1 ]
Das, Bhrigu Kumar [1 ]
Das, Trishna [1 ]
Azizov, Shavkatjon [2 ,3 ]
Kumar, Deepak [4 ]
机构
[1] Assam Sci & Technol Univ, Girijananda Chowdhury Inst Pharmaceut Sci, Dept Pharmacol, Gauhati 781017, Assam, India
[2] Uzbek Acad Sci, Inst Bioorgan Chem, Lab Biol Act Macromol Syst, Tashkent 100125, Uzbekistan
[3] Pharmaceut Tech Univ, Fac Life Sci, Tashkent 100084, Uzbekistan
[4] Shoolini Univ, Sch Pharmaceut Sci, Dept Pharmaceut Chem, Solan 173229, Himachal Prades, India
关键词
Paederia foetida; Medicinal plant; Pharmacological targets; Biological mechanism; ETHANOLIC EXTRACT; DIABETIC-NEPHROPATHY; IN-VITRO; APOPTOSIS; CELLS; INVOLVEMENT; ACTIVATION; EFFICACY; BEHAVIOR; INSULIN;
D O I
10.1007/s00210-023-02496-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Drug development from herbal medicines or botanical sources is believed to have a prominent role in the exploration of novel counteractive drugs that has sparked much interest in recent times. Paederia foetida is one such medicinal plant used in both traditional and folkloric medicine. Several parts of the herb are locally utilised as a natural curative agent for several ailments since time immemorial. Paederia foetida indeed possesses anti-diabetic, anti-hyperlipidaemic, antioxidant, nephro-protective, anti-inflammatory, antinociceptive, antitussive, thrombolytic, anti-diarrhoeal, sedative-anxiolytic, anti-ulcer, hepatoprotective activity, anthelmintic and anti-diarrhoeal activity. Furthermore, growing evidence shows many of its active constituents to be effective in cancer, inflammatory diseases, wound healing and spermatogenesis as well. These investigations shed light on possible pharmacological targets and attempts to establish a mechanism of action for these pharmacological effects. These findings contrast the significance of this medicinal plant for further research and for the exploration of novel counteractive drugs to establish a mechanism of action before being employed to healthcare.
引用
收藏
页码:2217 / 2240
页数:24
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