Diversified Synthesis of All-Carbon Quaternary gem-Difluorinated Cyclopropanes via Copper-Catalyzed Cross-Coupling

被引：13
|
作者：
Li, Bin [1 ,2 ,3 ]
Shi, Jiang-Ling [1 ,2 ,3 ]
Xia, Ying [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp 4, Chengdu 610041, Peoples R China
[3] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 15期
关键词：
CYCLOADDITION; ALKYNES;
D O I：
10.1021/acs.orglett.3c00751
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The construction of all-carbon quaternary centers in small-ring systems is important but challenging in organic synthesis. Herein, by taking gem-difluorocyclopropyl bromides (DFCBs) as a type of general and versatile building block, we developed a practical method for building all-carbon quaternary centers in gem-difluorinated cyclopropanes (DFCs). The reaction relies on the involvement of a gem-difluorocyclopropyl radical intermediate, which can couple with a wide range of nucleophiles under copper catalysis.
引用
收藏
页码：2674 / 2679
页数：6
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