Structural stability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes

被引:6
|
作者
Navickas, Z. [1 ]
Marcinkevicius, R. [2 ]
Telksniene, I. [1 ]
Telksnys, T. [1 ]
Ragulskis, M. [1 ]
机构
[1] Kaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, Lithuania
[2] Kaunas Univ Technol, Dept Software Engn, Kaunas, Lithuania
关键词
Hepatitis C model; solitary solution; structural stability; SOLITARY SOLUTIONS; EXP-FUNCTION; DYNAMICS;
D O I
10.1080/13873954.2024.2304808
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
The structural stability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes is investigated in this paper. The model is clinically verified to accurately reflect the viral dynamics of hepatitis C. It is demonstrated that the limit transition from the hepatitis C model to the Riccati system coupled with the diffusive terms leads to the elimination of the quadratic terms. Such a novel effect leads to the introduction of the concept of the deformed order-1 solitary solutions. The generalized operator of differentiation is used to construct the deformed order-1 solitary solutions to the Riccati system coupled with the diffusive terms. Finally, it is demonstrated that the Riccati system coupled with the diffusive terms admits non-deformed order-1 solitary solutions, which proves the structural instability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes.
引用
收藏
页码:51 / 72
页数:22
相关论文
共 50 条
  • [1] Transplantation of hepatitis C virus infected kidneys into hepatitis C virus uninfected recipients
    Sise, Meghan E.
    Chute, Donald F.
    Gustafson, Jenna L.
    Wojciechowski, David
    Elias, Nahel
    Chung, Raymond T.
    Williams, Winfred W.
    HEMODIALYSIS INTERNATIONAL, 2018, 22 : S71 - S80
  • [2] Transplanting Hepatitis C Virus-Infected or Uninfected Kidneys Into Hepatitis C Virus-Infected Recipients
    Kiberd, Bryce
    Doucette, Karen
    Vinson, Amanda
    Tennankore, Karthik
    ANNALS OF INTERNAL MEDICINE, 2018, 169 (12) : 897 - 898
  • [3] Transplanting Hepatitis C Virus-Infected or Uninfected Kidneys Into Hepatitis C Virus-Infected Recipients Response
    Eckman, Mark H.
    Woodle, E. Steve
    Thakar, Charuhas V.
    Paterno, Flavio
    Sherman, Kenneth E.
    ANNALS OF INTERNAL MEDICINE, 2018, 169 (12) : 898 - +
  • [4] Hepatitis C virus infected hepatocytes and apoptosis.
    Caronia, S
    Gulati, V
    McGarvey, MJ
    Goldin, RD
    Foster, GR
    HEPATOLOGY, 2000, 32 (04) : 265A - 265A
  • [5] Transplantation of hepatitis C infected kidneys into uninfected recipients. Why not?
    Franco, Antonio
    Balibrea, Noelia
    Gimeno, Angelina
    Merino, Esperanza
    Lopez, Maria Isabel
    Santiago, Carlos
    Perez Contreras, Francisco
    NEFROLOGIA, 2018, 38 (06): : 672 - 673
  • [6] Transplanting Hepatitis C Infected Organs Into Uninfected Recipients: A Pharmacy Perspective
    Holt, M. L.
    James, A.
    Gutierrez, K.
    Sparkman, T.
    Banbury, J.
    Jones, D.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 : 484 - 485
  • [7] NUCLEAR PLOIDY OF NORMAL AND NEOPLASTIC HEPATOCYTES FROM WOODCHUCK HEPATITIS VIRUS-INFECTED AND UNINFECTED WOODCHUCKS
    CULLEN, JM
    LINZEY, DW
    GEBHARD, DH
    HEPATOLOGY, 1994, 19 (05) : 1072 - 1078
  • [8] Metabolomic Profile of Hepatitis C Virus-Infected Hepatocytes
    Roe, Barbara
    Kensicki, Elizabeth
    Mohney, Robert
    Hall, William W.
    PLOS ONE, 2011, 6 (08):
  • [9] Does Transplantation of Hepatitis C Infected Kidneys Into Uninfected Recipients Cause Hepatitis C-Associated Kidney Injury?
    Naik, R. H.
    Shawar, S.
    Forbes, R. C.
    Schaefer, H.
    Shaffer, D.
    Rossi, M.
    Imperio, V.
    Concepcion, B. P.
    Kapp, M.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 : 825 - 826
  • [10] Transplanting Hepatitis C Virus-Infected Versus Uninfected Kidneys Into Hepatitis C Virus-Infected Recipients A Cost-Effectiveness Analysis
    Eckman, Mark H.
    Woodle, E. Steve
    Thakar, Charuhas V.
    Paterno, Flavio
    Sherman, Kenneth E.
    ANNALS OF INTERNAL MEDICINE, 2018, 169 (04) : 214 - +