Structural stability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes
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Navickas, Z.
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Marcinkevicius, R.
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Kaunas Univ Technol, Dept Software Engn, Kaunas, LithuaniaKaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, Lithuania
Marcinkevicius, R.
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Telksniene, I.
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Kaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, LithuaniaKaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, Lithuania
Telksniene, I.
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Telksnys, T.
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Kaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, LithuaniaKaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, Lithuania
Telksnys, T.
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Ragulskis, M.
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[1] Kaunas Univ Technol, Dept Math Modelling, Studentu 50-147, LT-51368 Kaunas, Lithuania
[2] Kaunas Univ Technol, Dept Software Engn, Kaunas, Lithuania
The structural stability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes is investigated in this paper. The model is clinically verified to accurately reflect the viral dynamics of hepatitis C. It is demonstrated that the limit transition from the hepatitis C model to the Riccati system coupled with the diffusive terms leads to the elimination of the quadratic terms. Such a novel effect leads to the introduction of the concept of the deformed order-1 solitary solutions. The generalized operator of differentiation is used to construct the deformed order-1 solitary solutions to the Riccati system coupled with the diffusive terms. Finally, it is demonstrated that the Riccati system coupled with the diffusive terms admits non-deformed order-1 solitary solutions, which proves the structural instability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes.
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Univ Coll Dublin, Ctr Res Infect Dis, Sch Med & Med Sci, Dublin 2, IrelandUniv Coll Dublin, Ctr Res Infect Dis, Sch Med & Med Sci, Dublin 2, Ireland
Roe, Barbara
Kensicki, Elizabeth
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Metabolon Inc, Durham, NC USAUniv Coll Dublin, Ctr Res Infect Dis, Sch Med & Med Sci, Dublin 2, Ireland
Kensicki, Elizabeth
Mohney, Robert
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Metabolon Inc, Durham, NC USAUniv Coll Dublin, Ctr Res Infect Dis, Sch Med & Med Sci, Dublin 2, Ireland
Mohney, Robert
Hall, William W.
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Univ Coll Dublin, Ctr Res Infect Dis, Sch Med & Med Sci, Dublin 2, IrelandUniv Coll Dublin, Ctr Res Infect Dis, Sch Med & Med Sci, Dublin 2, Ireland