共 3 条
Accuracy and reproducibility of a cone beam CT-based virtual parenchymal perfusion algorithm in the prediction of SPECT/CT anatomical and volumetric results during the planification of radioembolization for HCC
被引:3
|作者:
Derbel, Haytham
[1
,2
,3
]
Krichen, Mahdi
[1
]
Chalaye, Julia
[4
]
Saccenti, Laetitia
[1
,2
]
van der Sterren, William
[5
]
Muris, Anne-Hilde
[5
]
Lerman, Lionel
[4
]
Galletto, Athena
[1
]
Zaarour, Youssef
[1
]
Luciani, Alain
[1
,2
,3
]
Kobeiter, Hicham
[1
,2
,6
]
Tacher, Vania
[1
,2
,3
]
机构:
[1] Henri Mondor Univ Hosp, Assistance Publ Hop Paris AP HP, Dept Radiol, 51 Ave Marechal Lattre Tassigny, F-94010 Creteil, France
[2] Univ Paris Est Creteil, Creteil, France
[3] Henri Mondors Inst Biomed Res Inserm, Team 18 U955, Creteil, France
[4] Henri Mondor Univ Hosp, Dept Nucl Med, Assistance Publ, Creteil, France
[5] Philips Healthcare, Clin Sci & Med Affairs Dept, Image Guided Therapy Syst IGT S, Best, Netherlands
[6] Henri Mondors Inst Biomed Res Inserm, Team 8 U955, Creteil, France
关键词:
Hepatocellular carcinoma;
Cone-beam computed tomography;
Single-photon emission computed tomography;
Software;
Perfusion;
COLORECTAL LIVER METASTASES;
TRANSARTERIAL CHEMOEMBOLIZATION;
HEPATOCELLULAR-CARCINOMA;
Y-90;
SOFTWARE;
MICROSPHERES;
RADIOTHERAPY;
ANGIOGRAPHY;
D O I:
10.1007/s00330-023-09390-w
中图分类号:
R8 [特种医学];
R445 [影像诊断学];
学科分类号:
1002 ;
100207 ;
1009 ;
摘要:
ObjectivesTo evaluate anatomical and volumetric predictability of a cone beam computed tomography (CBCT)-based virtual parenchymal perfusion (VPP) software for the single-photon-emission computed tomography (SPECT)/CT imaging results during the work-up for transarterial radioembolization (TARE) procedure in patients with hepatocellular carcinoma (HCC).MethodsVPP was evaluated retrospectively on CBCT data of patients treated by TARE for HCC. Tc-99m macroaggregated albumin particles (Tc-99m-MAA) uptake territories on work-up SPECT/CT was used as ground truth for the evaluation. Semi-quantitative evaluation consisted of the ranking of visual consistency of the parenchymal enhancement and portal vein tumoral involvement on VPP and Tc-99m-MAA SPECT/CT, using a three-rank scale and two-rank scale, respectively. Inter-reader agreement was evaluated using a kappa coefficient. Quantitative evaluation included absolute volume error calculation and Pearson correlation between volumes enhanced territories on VPP and Tc-99m-MAA SPECT/CT.ResultsFifty-two CBCTs were performed in 33 included patients. Semi-quantitative evaluation showed a good concordance between actual Tc-99m-MAA uptake and the virtual enhanced territories in 73% and 75% of cases; a mild concordance in 12% and 10% and a poor concordance in 15%, for the two readers. Kappa coefficient was 0.86. Portal vein involvement evaluation showed a good concordance in 58.3% and 66.7% for the two readers, respectively, with a kappa coefficient of 0.82. Quantitative evaluation showed a volume error of 0.46 +/- 0.78 mL [0.01-3.55], and Pearson R-2 factor at 0.75 with a p value < 0.01.ConclusionCBCT-based VPP software is accurate and reliable to predict Tc-99m-MAA SPECT/CT anatomical and volumetric results in HCC patients during TARE.
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页码:3510 / 3520
页数:11
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