Effect of sex on the APOE4-aging interaction in the white matter microstructure of cognitively normal older adults using diffusion-tensor MRI with orthogonal-tensor decomposition (DT-DOME)

被引：1

作者：

Srisaikaew, Patcharaporn ^{[1
,2
]}

Chad, Jordan A. ^{[3
,4
]}

Mahakkanukrauh, Pasuk ^{[2
,5
]}

Anderson, Nicole D. ^{[3
,6
]}

Chen, J. Jean ^{[3
,4
,7
]}

机构：

[1] Chiang Mai Univ, Fac Med, PhD Program Anat, Chiang Mai, Thailand

[2] Chiang Mai Univ, Fac Med, Dept Anat, Chiang Mai, Thailand

[3] Baycrest Hlth Sci, Rotman Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[5] Chiang Mai Univ, Excellence Osteol Res & Training Ctr, Chiang Mai, Thailand

[6] Univ Toronto, Dept Psychol & Psychiat, Toronto, ON, Canada

[7] Univ Toronto, Inst Biomed Engn, Toronto, ON, Canada

来源：

FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷

基金：

加拿大健康研究院;

关键词：

apolipoprotein E4 gene; cognitively normal older adults; diffusion tensor imaging (DTI); tensor decomposition; white matter (WM); sex effects; mode of anisotropy (MO); norm of anisotropy (NA); APOLIPOPROTEIN-E GENOTYPE; APOE EPSILON-4 ALLELE; ALZHEIMERS-DISEASE; RISK-FACTORS; INTEGRITY; BRAIN; AGE; CARRIERS; GENDER; INTERVENTION;

D O I：

10.3389/fnins.2023.1049609

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of the apolipoprotein E epsilon 4 allele (APOE4) on brain microstructure of cognitively normal older adults remains incompletely understood, in part due to heterogeneity within study populations. In this study, we examined white-matter microstructural integrity in cognitively normal older adults as a function of APOE4 carrier status using conventional diffusion-tensor imaging (DTI) and the novel orthogonal-tensor decomposition (DT-DOME), accounting for the effects of age and sex. Age associations with white-matter microstructure did not significantly depend on APOE4 status, but did differ between sexes, emphasizing the importance of accounting for sex differences in APOE research. Moreover, we found the DT-DOME to be more sensitive than conventional DTI metrics to such age-related and sex effects, especially in crossing WM fiber regions, and suggest their use in further investigation of white matter microstructure across the life span in health and disease.

引用

页数：13