Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19

被引：1

作者：

Borgoyakova, M. B. ^{[1
]}

Karpenko, L. I. ^{[1
]}

Merkulyeva, I. A. ^{[1
]}

Shcherbakov, D. N. ^{[1
]}

Rudometov, A. P. ^{[1
]}

Starostina, E. V. ^{[1
]}

Shanshin, D. V. ^{[1
]}

Isaeva, A. A. ^{[1
]}

Nesmeyanova, V. S. ^{[1
]}

Volkova, N. V. ^{[1
]}

Belenkaya, S. V. ^{[1
]}

Volosnikova, E. A. ^{[1
]}

Zadorozhny, A. M. ^{[1
]}

Orlova, L. A. ^{[1
]}

Zaykovskaya, A. V. ^{[1
]}

Pyankov, O. V. ^{[1
]}

Bazhan, S. I. ^{[1
]}

Ilyichev, A. A. ^{[1
]}

机构：

[1] Fed Serv Oversight Consumer Protect & Welf, State Res Ctr Virol & Biotechnol VECTOR, Koltsov, Novosibirsk Reg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 174卷 / 02期

关键词：

SARS-CoV-2; DNA vaccines; subunit vaccines; DNA; protein vaccines; immune response;

D O I：

10.1007/s10517-023-05682-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such platform is the creation of vaccines combining DNA and protein components in one construct. For the creation of DNA vaccine, we chose the full-length spike protein (S) of the SARS-CoV-2 virus and used the recombinant receptor-binding domain (RBD) of the S protein produced in CHO-K1 cells as a protein component. The immunogenicity of the developed combined vaccine and its individual components was compared and the contribution of each component to the induction of the immune response was analyzed. The combined DNA/protein vaccine possesses the advantages of both underlying approaches and is capable of inducing both humoral (similar to subunit vaccines) and cellular (similar to DNA vaccines) immunity.

引用

页码：246 / 249

页数：4

共 50 条

[1] Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19
M. B. Borgoyakova
L. I. Karpenko
I. A. Merkulyeva
D. N. Shcherbakov
A. P. Rudometov
E. V. Starostina
D. V. Shanshin
A. A. Isaeva
V. S. Nesmeyanova
N. V. Volkova
S. V. Belenkaya
E. A. Volosnikova
A. M. Zadorozhny
L. A. Orlova
A. V. Zaykovskaya
O. V. Pyankov
S. I. Bazhan
A. A. Ilyichev
Bulletin of Experimental Biology and Medicine, 2022, 174 : 246 - 249
[2] Immunogenicity of a DNA vaccine candidate for COVID-19
Trevor R. F. Smith
Ami Patel
Stephanie Ramos
Dustin Elwood
Xizhou Zhu
Jian Yan
Ebony N. Gary
Susanne N. Walker
Katherine Schultheis
Mansi Purwar
Ziyang Xu
Jewell Walters
Pratik Bhojnagarwala
Maria Yang
Neethu Chokkalingam
Patrick Pezzoli
Elizabeth Parzych
Emma L. Reuschel
Arthur Doan
Nicholas Tursi
Miguel Vasquez
Jihae Choi
Edgar Tello-Ruiz
Igor Maricic
Mamadou A. Bah
Yuanhan Wu
Dinah Amante
Daniel H. Park
Yaya Dia
Ali Raza Ali
Faraz I. Zaidi
Alison Generotti
Kevin Y. Kim
Timothy A. Herring
Sophia Reeder
Viviane M. Andrade
Karen Buttigieg
Gan Zhao
Jiun-Ming Wu
Dan Li
Linlin Bao
Jiangning Liu
Wei Deng
Chuan Qin
Ami Shah Brown
Makan Khoshnejad
Nianshuang Wang
Jacqueline Chu
Daniel Wrapp
Jason S. McLellan
Nature Communications, 11
[3] Immunogenicity of a DNA vaccine candidate for COVID-19
Smith, Trevor R. F.
Patel, Ami
Ramos, Stephanie
Elwood, Dustin
Zhu, Xizhou
Yan, Jian
Gary, Ebony N.
Walker, Susanne N.
Schultheis, Katherine
Purwar, Mansi
Xu, Ziyang
Walters, Jewell
Bhojnagarwala, Pratik
Yang, Maria
Chokkalingam, Neethu
Pezzoli, Patrick
Parzych, Elizabeth
Reuschel, Emma L.
Doan, Arthur
Tursi, Nicholas
Vasquez, Miguel
Choi, Jihae
Tello-Ruiz, Edgar
Maricic, Igor
Bah, Mamadou A.
Wu, Yuanhan
Amante, Dinah
Park, Daniel H.
Dia, Yaya
Ali, Ali Raza
Zaidi, Faraz, I
Generotti, Alison
Kim, Kevin Y.
Herring, Timothy A.
Reeder, Sophia
Andrade, Viviane M.
Buttigieg, Karen
Zhao, Gan
Wu, Jiun-Ming
Li, Dan
Bao, Linlin
Liu, Jiangning
Deng, Wei
Qin, Chuan
Brown, Ami Shah
Khoshnejad, Makan
Wang, Nianshuang
Chu, Jacqueline
Wrapp, Daniel
McLellan, Jason S.
NATURE COMMUNICATIONS, 2020, 11 (01)
[4] Methotrexate and COVID-19 vaccine immunogenicity
Thorley, Jennifer
LANCET RHEUMATOLOGY, 2021, 3 (07): : E479 - E479
[5] Safety and Immunogenicity of the Convacell® Recombinant N Protein COVID-19 Vaccine
Rabdano, Sevastyan
Ruzanova, Ellina
Makarov, Denis
Vertyachikh, Anastasiya
Teplykh, Valeriya
Rudakov, German
Pletyukhina, Iuliia
Saveliev, Nikita
Zakharov, Konstantin
Alpenidze, Diana
Vasilyuk, Vasiliy
Arakelov, Sergei
Skvortsova, Veronika
VACCINES, 2024, 12 (01)
[6] COVID-19 vaccine immunogenicity in people with HIV
Costiniuk, Cecilia T.
Singer, Joel
Lee, Terry
Langlois, Marc-Andre
Arnold, Corey
Galipeau, Yannick
Needham, Judy
Kulic, Iva
Jenabian, Mohammad-Ali
Burchell, Ann N.
Shamji, Hasina
Chambers, Catharine
Walmsley, Sharon
Ostrowski, Mario
Kovacs, Colin
Tan, Darrell H. S.
Harris, Marianne
Hull, Mark
Brumme, Zabrina L.
Lapointe, Hope R.
Brockman, Mark A.
Margolese, Shari
Mandarino, Enrico
Samarani, Suzanne
Vulesevic, Branka
Lebouche, Bertrand
Angel, Jonathan B.
Routy, Jean-Pierre
Cooper, Curtis L.
Anis, Aslam H.
AIDS, 2023, 37 (01) : F1 - F10
[7] Vaccine against COVID-19
Picazo, Juan J.
REVISTA ESPANOLA DE QUIMIOTERAPIA, 2021, 34 (06) : 569 - 598
[8] Rational development of a combined mRNA vaccine against COVID-19 and influenza
Ye, Qing
Wu, Mei
Zhou, Chao
Lu, Xishan
Huang, Baoying
Zhang, Ning
Zhao, Hui
Chi, Hang
Zhang, Xiaojing
Ling, Dandan
Zhang, Rong-Rong
Li, Zhuofan
Luo, Dan
Huang, Yi-Jiao
Qiu, Hong-Ying
Song, Haifeng
Tan, Wenjie
Xu, Ke
Ying, Bo
Qin, Cheng-Feng
NPJ VACCINES, 2022, 7 (01)
[9] Rational development of a combined mRNA vaccine against COVID-19 and influenza
Qing Ye
Mei Wu
Chao Zhou
Xishan Lu
Baoying Huang
Ning Zhang
Hui Zhao
Hang Chi
Xiaojing Zhang
Dandan Ling
Rong-Rong Zhang
Zhuofan Li
Dan Luo
Yi-Jiao Huang
Hong-Ying Qiu
Haifeng Song
Wenjie Tan
Ke Xu
Bo Ying
Cheng-Feng Qin
npj Vaccines, 7
[10] Covid-19 vaccine trials: Ethnic diversity and immunogenicity
Jethwa, Hannah
Wong, Richard
Abraham, Sonya
VACCINE, 2021, 39 (27) : 3541 - 3543

← 1 2 3 4 5 →