Decoding the roles of heat shock proteins in liver cancer

被引：2

作者：

Sun, Chen ^{[1
]}

Pan, Qi ^{[2
]}

Du, Mingyang ^{[1
]}

Zheng, Jiahe ^{[1
]}

Bai, Ming ^{[3
]}

Sun, Wei ^{[4
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Radiol, Shenyang 110004, Peoples R China

[2] China Med Univ, Hosp 1, Dept Hepatobiliary Surg & Organ Transplantat, Shenyang 110004, Peoples R China

[3] China Med Univ, Hosp 1, Dept Med Oncol 2, Shenyang 110001, Peoples R China

[4] China Med Univ, Shengjing Hosp, Dept Radiol, Shenyang, Liaoning, Peoples R China

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2024年 / 75卷

关键词：

Hepatocellular carcinoma; Heat shock protein; Tumorigenesis; Diagnosis; Therapy; HEPATOCELLULAR-CARCINOMA CELLS; DENDRITIC CELLS; GLUTAMINE-SYNTHETASE; MOLECULAR CHAPERONE; HSP90; INHIBITOR; REVERSE-TRANSCRIPTASE; DOWN-REGULATION; UP-REGULATION; TUMOR-CELLS; IN-VITRO;

D O I：

10.1016/j.cytogfr.2023.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the most common gastrointestinal malignancies, characterized by insidious onset and high propensity for metastasis and recurrence. Apart from surgical resection, there are no effective curative methods for HCC in recent years, due to resistance to radiotherapy and chemotherapy. Heat shock proteins (HSP) play a crucial role in maintaining cellular homeostasis and normal organism development as molecular chaperones for intracellular proteins. Both basic research and clinical data have shown that HSPs are crucial participants in the HCC microenvironment, as well as the occurrence, development, metastasis, and resistance to radiotherapy and chemotherapy in various malignancies, particularly liver cancer. This review aims to discuss the molecular mechanisms and potential clinical value of HSPs in HCC, which may provide new insights for HSP-based therapeutic interventions for HCC.

引用

页码：81 / 92

页数：12

共 50 条

[1] Expression and roles of heat shock proteins in human breast cancer
Yano, M
Naito, Z
Tanaka, S
Asano, G
JAPANESE JOURNAL OF CANCER RESEARCH, 1996, 87 (09): : 908 - 915
[2] Heat shock proteins and their physiological roles
Askar, Tuenay Kontas
Ergun, Nuray
Turunc, Vecihe
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, 2007, 13 (01) : 109 - 114
[3] Heat Shock Proteins and Ovarian Cancer: Important Roles and Therapeutic Opportunities
Hoter, Abdullah
Naim, Hassan Y.
CANCERS, 2019, 11 (09)
[4] THE ROLES OF HEAT-SHOCK PROTEINS IN PLANTS
VIERLING, E
ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1991, 42 : 579 - 620
[5] New roles for heat-shock proteins
Everts, Sarah
CHEMICAL & ENGINEERING NEWS, 2016, 94 (43) : 5 - 5
[6] Immunological roles of extracellular heat shock proteins
Binder, Robert
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (02) : A3 - A3
[7] Heat Shock Proteins and Cancer
Wu, Jianming
Liu, Tuoen
Rios, Zechary
Mei, Qibing
Lin, Xiukun
Cao, Shousong
TRENDS IN PHARMACOLOGICAL SCIENCES, 2017, 38 (03) : 226 - 256
[8] Heat shock proteins in cancer
Sherman, Michael
Multhoff, Gabriele
STRESS RESPONSES IN BIOLOGY AND MEDICINE: STRESS OF LIFE IN MOLECULES, CELLS, ORGANISMS, AND PSYCHOSOCIAL COMMUNITIES, 2007, 1113 : 192 - 201
[9] Roles of Heat Shock Proteins and γδT Cells in Inflammation
Hirsh, Mark I.
Junger, Wolfgang G.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2008, 39 (05) : 509 - 513
[10] Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer
Ikwegbue, Paul Chukwudi
Masamba, Priscilla
Oyinloye, Babatunji Emmanuel
Kappo, Abidemi Paul
PHARMACEUTICALS, 2018, 11 (01)

← 1 2 3 4 5 →