The Scientific Revolution represents a turning point in the history of humanity. Yet it remains ill -understood, partly because of a lack of quantification. Here, we leverage large datasets of individual biographies (N = 22,943) and present the first estimates of scientific production during the late medieval and early modern period (1300-1850). Our data reveal striking differences across countries, with England and the United Provinces being much more creative than other countries, suggesting that economic development has been key in generating the Scientific Revolution. In line with recent results in behavioural sciences, we show that scientific creativity and economic development are associated with other kinds of creative activities in philosophy, literature, music and the arts, as well as with inclusive institutions and ascetic religiosity, suggesting a common underlying mindset associated with long-term orientation and exploration. Finally, we investigate the interplay between economic development and cultural transmission (the so-called Republic of Letters') using partially observed Markov models imported from population biology. Surprisingly, the role of horizontal transmission (from one country to another) seems to have been marginal. Beyond the case of science, our results suggest that economic development is an important factor in the evolution of aspects of human culture.
