A novel missing data imputation approach based on clinical conditional Generative Adversarial Networks applied to EHR datasets

The missing data mechanism is a relevant problem in Machine Learning (ML) and biomedical informatics communities. Real-world Electronic Health Record (EHR) datasets comprise several missing values, thus revealing a high level of spatiotemporal sparsity in the predictors' matrix. Several approaches in the state-of-the-art tried to deal with this problem by proposing different data imputation strategies that (i) are often unrelated to the ML model, (ii) are not conceived for EHR data where laboratory exams are not prescribed uniformly over time and percentage of missing values is high (iii) exploit only univariate and linear information on the observed features. Our paper proposes a data imputation strategy based on a clinical conditional Generative Adversarial Network (ccGAN) capable of imputing missing values by exploiting non-linear and multivariate information across patients. Unlike other GAN data imputation-based approaches, our method deals explicitly with the high level of missingness of routine EHR data by conditioning the imputing strategy to the observable values and those fully-annotated. We demonstrated the statistical significance of the ccGAN to other state-of-the-art approaches in terms of imputation (around 19.79% of gain to the best competitor) and predictive performance (up to 1.60% of gain to the best competitor) on a real multi-diabetic centers dataset. We also demonstrated its robustness across different missingness rates (up to 1.61% of gain to the best competitor in the highest missingness rates condition) on an additional benchmark EHR dataset.