Copper-catalyzed radical trifluoromethylalkynylation of unactivated alkenes with terminal alkynes

被引：6

作者：

Ren, Yang-Qing ^{[1
,2
,3
]}

Yang, Chang-Jiang ^{[1
]}

Li, Zhong-Liang ^{[4
,5
]}

Gu, Qiang-Shuai ^{[4
]}

Liu, Lin ^{[1
]}

Liu, Xin-Yuan ^{[2
,3
]}

机构：

[1] Great Bay Univ, Inst Sci Res, Sch Sci, Dongguan 523000, Peoples R China

[2] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China

[3] Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China

[4] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China

[5] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2023年 / 267卷

基金：

中国国家自然科学基金;

关键词：

Trifluoromethylalkynylation; Terminal alkyne; Radical reaction; Copper; Unactivated alkenes; C-H BONDS; FLUORINE; ALKYNYLATION; 1,2-DIFUNCTIONALIZATION; 1,2-ADDITION; ELIMINATION; STYRENES; BROMIDES; IODIDES; SILVER;

D O I：

10.1016/j.jfluchem.2023.110107

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A copper-catalyzed three-component radical trifluoromethylalkynylation of unactivated alkenes is realized from Togni-II reagent and readily available terminal alkynes under mild conditions to afford an array of beta-tri- fluoromethylated alkynes. The utilization of a multidentate N,N,N-ligand is crucial for the efficient radical generation and the C(sp3)-C(sp) bond formation. Facile transformations of the difunctionalization products highlight its potential utility in the synthesis of various trifluoromethyl-containing building blocks.

引用

页数：6

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