Gut mycobiome: A "black box" of gut microbiome-host interactions

被引:2
|
作者
Zhao, Xinyue [1 ]
Hu, Xiaomin [2 ]
Han, Junjie [3 ]
Yin, Ruopeng [3 ,4 ]
Zhang, Shuyang [1 ,5 ]
Liu, Hongwei [3 ,4 ,6 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Cardiol, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Med Res Ctr, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
[3] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China
[4] Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China
[5] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Cardiol, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China
[6] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
关键词
Candida albicans; crosstalk; gut; immunity; mycobiome; CANDIDA GASTROINTESTINAL COLONIZATION; COMMENSAL FUNGI; ALBICANS; IMMUNITY; RESPONSES;
D O I
10.1002/wsbm.1611
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Fungi, being a necessary component of the gut microbiome, potentially have direct or indirect effects on the health and illness status of the host. The gut mycobiome is an inducer of the host's immunity, maintaining intestinal homeostasis, and protecting against infections, as well as a reservoir of opportunistic microorganisms and a potential cofactor when the host is immunocompromised. In addition, gut fungi interact with a diverse range of microbes in the intestinal niches. In this article, we reviewed the composition of gut mycobiome, their association with host health and illness, and summarized the specific Candida albicans-host interactions, in order to provide insights and directions for the ongoing study of fungi.This article is categorized under:Infectious Diseases > Molecular and Cellular Physiology
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页数:18
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