The association of interleukin-10 single nucleotide polymorphisms (rs1800871) and serum levels in Iraqi patients with celiac disease: A case-control study

Background: Celiac disease is one of the autoimmune diseases resulting from ingesting gluten, in addition to the diverse microbiota in the gut, micronutrient deficiencies, and genetic predisposition. Several immunological factors impact celiac disease pathogenesis; interleukin-10 is one of these immunological factors that have a role in disease development. Methods: The present study was designed to examine the genotypes and alleles frequency of IL10 rs1800871in celiac disease patients compared to the healthy control volunteers using allele-specific primers-polymerase chain reaction technique. Fifty celiac disease patients volunteered to participate in the current study (age mean +/- SD was 23.5 +/- 11.88 years) who enrolled during the period from November 2021-February 2022, compared with 50 healthy volunteers (age mean +/- SD was 23.5 +/- 11.88 years). Results: The genetic variations of IL-10 SNPs rs1800871 results showed that the TT genotype and T allele were more frequent than the other genotypes and allele C in the patients' group (58.0% and 73.0% vs 30.0%, 12.0% and 27.0%, respectively). Also, the TT genotype and T allele have higher OR values than the CC, CT genotypes and C allele in the patients' group (15.88 and 7.70 vs 0.11, 0.76 and 0.13, respectively). These findings might be due to the risk of TT and T in the disease development than CC, CT/C genotypes/allele. Conclusion: From the obtained results, the present study concluded that the TT/T genotype/allele might be associated with autoimmune disease development, such as celiac disease, more than the other genotypes.