Comparing chronic obstructive pulmonary disease and depressive disorder in terms of inflammation-related biomarkers

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by the presence of depressive symptoms. Methods: Cytokine and deiodinase iodothyronines (DIOs) levels were evaluated in COPD patients and patients diagnosed with depressive disorder and control individuals. using enzyme-linked immunosorbent assays. Results: Interleukin 1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) levels were higher in COPD and depression patients than in control individuals. DIO2 were significantly lower in COPD and recurrent depressive disorder (rDD) patients than in controls. Conclusions: Changes in the levels of IL-1 beta, TNF-alpha and DIO2 in COPD patients may explain the presence of depression in COPD patients.