Early screening of nasopharyngeal carcinoma

被引：7
|
作者：
Yuan, Yue [1 ,2 ]
Ye, Fei [1 ,2 ,3 ]
Wu, Jian-Hui [2 ]
Fu, Xiao-Yan [4 ,5 ]
Huang, Zhong-Xi [6 ]
Zhang, Tao [1 ]
机构：
[1] Jinan Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Guangzhou, Peoples R China
[2] Zhongshan City Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Zhongshan, Guangdong, Peoples R China
[3] Huangpu Hosp, Dept Otolaryngol Head & Neck Surg, Zhongshan, Guangdong, Peoples R China
[4] Southern Med Univ, Shenzhen Hosp, Dept Pediat Otolaryngol, Shenzhen, Peoples R China
[5] Southern Med Univ, Sch Clin Med 3, Guangzhou, Peoples R China
[6] Southern Med Univ, Canc Res Inst, Sch Basic Med Sci, Guangzhou 510515, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 10期
关键词：
cfDNA; DNA methylation; early screening; EBV; nasopharyngeal carcinoma; EPSTEIN-BARR-VIRUS; DNA METHYLATION; PROMOTER HYPERMETHYLATION; DIAGNOSIS; PLASMA; CANCER; EPIGENETICS; PERFORMANCE; BIOMARKER; MARKERS;
D O I：
10.1002/hed.27466
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The low positive predictive value (PPV) of early screening of nasopharyngeal carcinoma (NPC) is the problems that need to be solved urgently. The combination of cell-free DNA (cfDNA) methylation testing and Epstein-Barr virus (EBV) serological testing is the key to solve this problem. This paper reviews recent advances in early screening for NPC and cfDNA methylation, with future perspectives. Pubmed was searched for the literature related to early screening of NPC and cfDNA methylation in the past 5 years. The results of these studies were summarized. Despite these efforts, the PPV is still low (10%). Previous studies have shown that cfDNA methylation analysis has good specificity and accuracy across a variety of tumors. The combination of cfDNA methylation and EBV detection helps to improve the PPV for early screening of NPC. The combination of cfDNA methylation and EBV serological testing is key to addressing the low PPV of NPC early screening.
引用
收藏
页码：2700 / 2709
页数：10
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