Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors

被引：30

作者：

Meloni, Antonella ^{[1
]}

Cadeddu, Christian ^{[2
]}

Cugusi, Lucia ^{[3
]}

Donataccio, Maria Pia ^{[4
]}

Deidda, Martino ^{[2
]}

Sciomer, Susanna ^{[5
]}

Gallina, Sabina ^{[6
]}

Vassalle, Cristina ^{[7
]}

Moscucci, Federica ^{[5
]}

Mercuro, Giuseppe ^{[2
]}

Maffei, Silvia ^{[8
]}

机构：

[1] Fdn G Monasterio CNR Reg Toscana, Dept Radiol, I-56124 Pisa, Italy

[2] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09042 Cagliari, Italy

[3] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy

[4] European Hosp, Cardiol Unit, I-00149 Rome, Italy

[5] Univ Rome Sapienza, Dept Clin & Internal Med Anesthesiol & Cardiovasc, Policlin Umberto 1, I-00185 Rome, Italy

[6] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, I-66100 Chieti, Italy

[7] Fdn G Monasterio CNR Reg Toscana, Med Lab, I-56124 Pisa, Italy

[8] Fdn G Monasterio CNR Reg Toscana, Endocrinol Cardiovasc Ginecolog Osteoporosi, I-56124 Pisa, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 02期

关键词：

metabolic syndrome; gender; cardiovascular disease; risk factors; FATTY LIVER-DISEASE; CORONARY-HEART-DISEASE; GESTATIONAL DIABETES-MELLITUS; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CHOLESTEROL EDUCATION-PROGRAM; IMPAIRED GLUCOSE-TOLERANCE; POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; SEX-DIFFERENCES;

D O I：

10.3390/ijms24021588

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic syndrome (Mets) is a clinical condition characterized by a cluster of major risk factors for cardiovascular disease (CVD) and type 2 diabetes: proatherogenic dyslipidemia, elevated blood pressure, dysglycemia, and abdominal obesity. Each risk factor has an independent effect, but, when aggregated, they become synergistic, doubling the risk of developing cardiovascular diseases and causing a 1.5-fold increase in all-cause mortality. We will highlight gender differences in the epidemiology, etiology, pathophysiology, and clinical expression of the aforementioned Mets components. Moreover, we will discuss gender differences in new biochemical markers of metabolic syndrome and cardiovascular risk.

引用

页数：17

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