TBAT-Catalyzed Deoxygenative Reduction of Tertiary Amides to Amines

被引：6

作者：

Vinayagam, Vinothkumar ^{[1
]}

Sadhukhan, Subir Kumar ^{[1
]}

Karre, Satish Kumar ^{[1
]}

Srinath, Ravuri ^{[1
]}

Maroju, Ravi Kumar ^{[1
]}

Karra, Purushotham Reddy ^{[1
]}

Bathula, Hema Sundar Naveen Babu ^{[1
]}

Kundrapu, Siva ^{[1
]}

Surukonti, Srikanth Reddy ^{[1
]}

机构：

[1] Curia India Pvt Ltd, Med Chem Div, Hyderabad Res Ctr, Albany Mol Res, Hyderabad 500078, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 25期

关键词：

CARBOXYLIC-ACID DERIVATIVES; CHEMOSELECTIVE REDUCTION; SECONDARY AMIDES; TETRABUTYLAMMONIUM TRIPHENYLDIFLUOROSILICATE; FLUORIDE SOURCE; HYDROGENATION; ALDEHYDES; HYDROSILYLATION; SILICON; KETONES;

D O I：

10.1021/acs.orglett.3c01150

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, mild, metal-free catalytic protocol is developed to convert amides to amines. This protocol uses a stable tetrabutylammonium difluorotriphenylsilicate in combination with silanes that generates a highly reactive hydrosilicate species, which enables the reduction of a broad range of amides to amines in moderate to good yields. The attractive features of this protocol include operational simplicity, safety, short reaction times, room temperature reaction, broad substrate scope, and amenable to scale up.

引用

页码：4610 / 4614

页数：5

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