Electrochemical behavior and voltammetric determination of nicardipine based on reduced graphene oxide/polydiallyl dimethylammonium chloride/nanosilver modified electrode

Reduced graphene oxide/polydiallyl dimethylammonium chloride/silver nanoparticles (rGO/PDDA/AgNPs) composite material was fabricated, and characterized by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). A sensitive electrochemical sensor was constructed based on rGO /PDDA/AgNPs hybrid modified glassy carbon electrode for the determination of nicardipine (NP). The electrochemical behavior of NP on this sensor was investigated by cyclic voltammetry (CV). The measurement conditions such as supporting electrolyte and scanning speed were also optimized. Under optimized conditions, this proposed sensor showed a good linear relationship between the peak current and the concentration of NP in the range of 1.0 x 10(-7) similar to 1.2 x 10(-4) M, and the detection limit was 3.3 x 10(-8) M. The possible interference of different compounds on the determination of NP was investigated in detail. The recovery of NP was 98.0 similar to 104.1%, which indicated that the composite modified electrode had high accuracy. This electrochemical method is low cost, sensitive, and can be applied to the determination of NP in drugs or preparations.