Residual Lung Abnormalities after COVID-19 Hospitalization Interim Analysis of the UKILD Post-COVID-19 Study

被引：64

作者：

Stewart, Iain ^{[1
]}

Jacob, Joseph ^{[2
]}

George, Peter M. ^{[5
]}

Molyneaux, Philip L. ^{[1
]}

Porter, Joanna C. ^{[4
]}

Allen, Richard J. ^{[6
,7
]}

Aslani, Shahab ^{[2
]}

Baillie, J. Kenneth ^{[9
]}

Barratt, Shaney L. ^{[10
]}

Beirne, Paul ^{[11
]}

Bianchi, Stephen M. ^{[12
]}

Blaikley, John F. ^{[13
]}

Chalmers, James D. ^{[14
]}

Chambers, Rachel C. ^{[3
]}

Chadhuri, Nazia ^{[13
]}

Coleman, Christopher ^{[15
]}

Collier, Guilhem ^{[16
]}

Denneny, Emma K. ^{[4
]}

Docherty, Annemarie ^{[9
]}

Elneima, Omer ^{[7
]}

Evans, Rachael A. ^{[7
]}

Fabbri, Laura ^{[1
]}

Gibbons, Michael A. ^{[17
]}

Gleeson, Fergus, V ^{[18
]}

Gooptu, Bibek ^{[6
]}

Greening, Neil J. ^{[7
]}

Guio, Beatriz Guillen ^{[6
]}

Hall, Ian P. ^{[15
]}

Hanley, Neil A. ^{[13
]}

Harris, Victoria ^{[7
]}

Harrison, Ewen M. ^{[9
]}

Heightman, Melissa ^{[19
]}

Hillman, Toby E. ^{[19
]}

Horsley, Alex ^{[13
]}

Houchen-Wolloff, Linzy ^{[7
]}

Jarrold, Ian ^{[20
]}

Johnson, Simon R. ^{[15
]}

Jones, Mark G. ^{[21
]}

Khan, Fasihul ^{[15
]}

Lawson, Rod ^{[12
]}

Leavy, Olivia ^{[6
]}

Lone, Nazir ^{[8
]}

Marks, Michael ^{[19
]}

McAuley, Hamish ^{[7
]}

Mehta, Puja ^{[19
]}

Parekh, Dhruv ^{[22
]}

Hanley, Karen Piper ^{[13
,23
]}

Plate, Manuela ^{[19
]}

Pearl, John ^{[6
]}

Poinasamy, Krisnah ^{[20
]}

机构：

[1] Imperial Coll London, Natl Heart & Lung Inst, Emmanuel Kaye Bldg, London SW3 6LY, England

[2] Ctr Med Imaging Comp, London, England

[3] Resp Med, London, England

[4] UCL, London, England

[5] Guys & St Thomas NHS Fdn Trust, Royal Brompton & Harefield Clin Grp, London, England

[6] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England

[7] Leicester NIHR Biomed Res Ctr, Leicester, Leics, England

[8] Usher Inst, Edinburgh, Midlothian, Scotland

[9] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[10] North Bristol NHS Trust, Bristol, Avon, England

[11] Leeds Teaching Hosp NHS Fdn Trust, Leeds, W Yorkshire, England

[12] Sheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England

[13] Univ Manchester, Manchester, Lancs, England

[14] Ninewells Hosp & Med Sch, Dundee, Scotland

[15] Univ Nottingham, Nottingham, England

[16] Univ Sheffield, Sheffield, S Yorkshire, England

[17] Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England

[18] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[19] Univ Coll London Hosp, London, England

[20] Asthma Lung UK, London, England

[21] Univ Southampton, Fac Med, Southampton, Hants, England

[22] Univ Birmingham, Birmingham, England

[23] Manchester Univ NHS Fdn Trust, Manchester, Lancs, England

[24] Univ Oxford, Oxford, England

[25] Univ Liverpool, Liverpool, Merseyside, England

[26] Newcastle Univ, Newcastle, NSW, Australia

[27] Perth Royal Infirm, NHS Tayside, Perth, Scotland

[28] Liverpool Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2023年 / 207卷 / 06期

基金：

英国科研创新办公室;

关键词：

COVID-19; hospitalization; HRCT; lung damage; lung abnormalities;

D O I：

10.1164/rccm.202203-0564OC

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19) and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to progressive lung damage. Objectives: The UK Interstitial Lung Disease Consortium (UKILD) post-COVID-19 study interim analysis was planned to estimate the prevalence of residual lung abnormalities in people hospitalized with COVID-19 on the basis of risk strata. Methods: The PHOSP-COVID-19 (Post-Hospitalization COVID-19) study was used to capture routine and research follow-up within 240 days from discharge. Thoracic computed tomography linked by PHOSP-COVID-19 identifiers was scored for the percentage of residual lung abnormalities (ground-glass opacities and reticulations). Risk factors in linked computed tomography were estimated with Bayesian binomial regression, and risk strata were generated. Numbers within strata were used to estimate posthospitalization prevalence using Bayesian binomial distributions. Sensitivity analysis was restricted to participants with protocol-driven research follow-up. Measurements and Main Results: The interim cohort comprised 3,700 people. Of 209 subjects with linked computed tomography (median, 119 d; interquartile range, 83-155), 166 people (79.4%) had more than 10% involvement of residual lung abnormalities. Risk factors included abnormal chest X-ray (risk ratio [RR], 1.21; 95% credible interval [CrI], 1.05-1.40), percent predicted DLCO less than 80% (RR, 1.25; 95% CrI, 1.00-1.56), and severe admission requiring ventilation support (RR, 1.27; 95% CrI, 1.07-1.55). In the remaining 3,491 people, moderate to very high risk of residual lung abnormalities was classified at 7.8%, and posthospitalization prevalence was estimated at 8.5% (95% CrI, 7.6-9.5), rising to 11.7% (95% CrI, 10.3-13.1) in the sensitivity analysis. Conclusions: Residual lung abnormalities were estimated in up to 11% of people discharged after COVID-19-related hospitalization. Health services should monitor at-risk individuals to elucidate long-term functional implications.

引用

页码：693 / 703

页数：11

共 50 条

[1] Lungs after COVID-19: Evolving Knowledge of Post-COVID-19 Interstitial Lung Disease
Aronson, Kerri I.
Podolanczuk, Anna J.
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2021, 18 (05) : 773 - 774
[2] Persistent abnormalities on echocardiography post hospitalization for COVID-19
Vijayakumar, Bavithra
Tonkin, James
Shah, Pallav L.
EUROPEAN RESPIRATORY JOURNAL, 2021, 58
[3] Post-COVID-19 tomographic abnormalities
Sawamura, M. V. Y.
Verrastro, C. G. Y.
Ferreira, E. V. M.
de Albuquerque, A. L. P.
Ribeiro, S. M.
Auad, R., V
Sperandio, P. C. de Abreu
Souza, V. C.
Lima, M. L.
Prudente, R. A.
Franco, E. T.
Franco, A. C.
Baldi, B. G.
Tanni, S. E.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2022, 26 (07) : 629 - 635
[4] Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosis
Zhong, Han
Zhou, Yang
Mei, Shu-Ya
Tang, Ri
Feng, Jin-Hua
He, Zheng-Yu
Xu, Qiao-Yi
Xing, Shun-Peng
FRONTIERS IN PUBLIC HEALTH, 2022, 10
[5] Post-COVID-19 syndrome in a cohort of COVID-19
Bildirici, Yasar
Metintas, Selma
Ucan, Anil
Ak, Guntulu
Guvenc, Sebnem Eker
Metintas, Muzaffer
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2023, 27 (17) : 8291 - 8300
[6] Quality of Life in Post-COVID-19 Patients after Hospitalization
Mitrovic-Ajtic, Olivera
Stanisavljevic, Dejana
Miljatovic, Sanja
Dragojevic, Teodora
Zivkovic, Emilija
Sabanovic, Milos
Cokic, Vladan P.
HEALTHCARE, 2022, 10 (09)
[7] Diagnostic performance of radiologists in distinguishing post-COVID-19 residual abnormalities from interstitial lung abnormalities
Lee, Jong Eun
Lee, Hyo-Jae
Park, Gyeryeong
Chae, Kum Ju
Jin, Kwang Nam
Castaner, Eva
Ghaye, Benoit
Ko, Jane P.
Prosch, Helmut
Simpson, Scott
Larici, Anna Rita
Kanne, Jeffrey P.
Frauenfelder, Thomas
Jeong, Yeon Joo
Yoon, Soon Ho
EUROPEAN RADIOLOGY, 2025, 35 (04) : 2265 - 2274
[8] Residual lung abnormalities after 12 months of COVID19 hospitalization: A brazilian multicenter study
Lafeta, Mariana Lima
Souza, Vitor C.
Penido, Fabiana Oliveira
Saldanha, Maria Fernanda
Prudente, Robson Aparecido
Brizola, Luiz Fernando Pereira
Franco, Estefania Aparecida Thome
Folchino, Flavia Neri
Lopes, Eliana Bandini Risso Ribeiro
Albuquerque, Andre Luiz Pereira
Tanni, Suzana Erico
Izbicki, Meyer
Nery, Luiz Eduardo
Oliveira, Rudolf K. F.
Sperandio, Priscila A.
Ferreira, Eloara Vm
EUROPEAN RESPIRATORY JOURNAL, 2024, 64
[9] Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans*
Hino, Takuya
Nishino, Mizuki
Valtchinov, Vladimir I.
Gagne, Staci
Gay, Elizabeth
Wada, Noriaki
Tseng, Shu Chi
Madore, Bruno
Guttmann, Charles R. G.
Ishigami, Kousei
Li, Yi
Christiani, David C.
Hunninghake, Gary M.
Levy, Bruce D.
Kaye, Kenneth M.
Hatabu, Hiroto
EUROPEAN JOURNAL OF RADIOLOGY OPEN, 2023, 10
[10] Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)
Wild, Jim M.
Porter, Joanna C.
Molyneaux, Philip L.
George, Peter M.
Stewart, Iain
Allen, Richard James
Aul, Raminder
Baillie, John Kenneth
Barratt, Shaney L.
Beirne, Paul
Bianchi, Stephen M.
Blaikley, John F.
Brooke, Jonathan
Chaudhuri, Nazia
Collier, Guilhem
Denneny, Emma K.
Docherty, Annemarie
Fabbri, Laura
Gibbons, Michael A.
Gleeson, Fergus, V
Gooptu, Bibek
Hall, Ian P.
Hanley, Neil A.
Heightman, Melissa
Hillman, Toby E.
Johnson, Simon R.
Jones, Mark G.
Khan, Fasihul
Lawson, Rod
Mehta, Puja
Mitchell, Jane A.
Plate, Manuela
Poinasamy, Krisnah
Quint, Jennifer K.
Rivera-Ortega, Pilar
Semple, Malcolm
Simpson, A. John
Smith, D. J. F.
Spears, Mark
Spencer, Lisa G.
Stanel, Stefan C.
Thickett, David R.
Thompson, A. A. Roger
Walsh, Simon L. F.
Weatherley, Nicholas D.
Weeks, Mark Everard
Wootton, Dan G.
Brightling, Chris E.
Chambers, Rachel C.
Ho, Ling-Pei
BMJ OPEN RESPIRATORY RESEARCH, 2021, 8 (01)

← 1 2 3 4 5 →