Combined intramyocardial injectable hydrogel and pericardial adhesive hydrogel patch therapy strategy to achieve gene/ion/gas delivery for improving cardiac function

被引：19

作者：

Zhang, Xiaoping ^{[1
]}

Sun, Yage ^{[1
]}

Wu, Tengling ^{[1
]}

Zhao, Xinrui ^{[1
]}

Yang, Rong ^{[1
]}

Wang, Hongying ^{[1
]}

Liu, Wenguang ^{[1
]}

机构：

[1] Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300350, Peoples R China

来源：

NANO TODAY | 2023年 / 50卷

基金：

中国国家自然科学基金;

关键词：

Injectable hydrogel; Adhesive hydrogel patch; Drug delivery; Gene; ion; gas therapy; Myocardial infarction; SYSTEM; REPAIR; HEART; REGENERATION; DOXORUBICIN; MODULATION; CELLS; OXIDE;

D O I：

10.1016/j.nantod.2023.101861

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Circular RNA (circRNA), bioactive ion and nitric oxide (NO) are beneficial to myocardial repair after myo-cardial infarction (MI); however, to achieve efficient intervention of circRNA and delivery of NO and ion throughout myocardium still remains difficult. Injectable hydrogels have been frequently used to release angiogenic factors; however, due to the limited drug diffusion distance, angiogenic factors are difficult to reach the epicardium - a viable target for angiogenesis. Herein, a combined strategy based on coadmi-nistration of lipo/pcircRNA and strontium ions-containing nanoparticles-encapsulated injectable hydrogel and NO-bearing liposome-loaded pericardial adhesive hydrogel patch is proposed to realize intramyocardial gene/ion delivery and epicardial NO delivery to inhibit cardiomyocyte apoptosis and inflammatory re-sponse, and circumvent insufficient angiogenesis problem. The hydrogel prepared via Schiff-reaction of hydrazide-hyaluronic acid and aldehydated-laminarin with self-immunoregulation function is injected into the myocardium to deliver lipo/pcircRNA nanoparticles and strontium ions to inhibit cardiomyocyte apoptosis and partially promote angiogenesis. To further boost angiogenesis, an adhesive hyaluronic acid-based hydrogel is bonded to the myocardial surface by pre-anchored sponge that can remove hydration layer, to achieve the release of NO nanodrug in epicardium. This combination therapy contributes to a significant inhibition of cardiomyocyte apoptosis and inflammatory response and maximum angiogenesis, thus improving cardiac function. (c) 2023 Elsevier Ltd. All rights reserved.

引用

页数：15