Design of Efficient Point-Mass Filter for Linear and Nonlinear Dynamic Models

Impaired wound healing is a common complication of orthopedic surgery and poses a difficult challenge in the clinic. Fibroblasts are thought to play a significant role in wound healing, and can be positively affected by IP: 2038 0920 On: Tue 13 Jun 2023 07:07 14 low concentrations of rapamycin; hwever, rapamyciis cytotoxic at higher concentrations. To address this issue, a RAPA/PLGA-PEG drug delivery system was constructed in this study to maintain low concentrations Delivered by Ingenta of rapamycin. The results showed that the nanoparticles were stable, had good sustained drug release properties and were able to reduce the toxicity of rapamycin to fibroblasts. These findings suggest that RAPA/PLGA-PEG nanoparticles can reduce the cytotoxicity of rapamycin and may be a potential clinical treatment for impaired wound healing.