Nucleic Acid Delivery Nanotechnologies for In Vivo Cell Programming

被引：1
|
作者：
Balcorta, Hannia V. [1 ]
Contreras Guerrero, Veronica G. [1 ]
Bisht, Deepali [1 ]
Poon, Wilson [1 ]
机构：
[1] Univ Texas El Paso, Coll Engn, Dept Met Mat & Biomed Engn, El Paso, TX 79968 USA
来源：
ACS APPLIED BIO MATERIALS | 2024年 / 7卷 / 08期
关键词：
nucleic acid delivery; gene delivery; genetherapy; cell programming; nanoparticles; viral vectors; GENE-THERAPY; MESSENGER-RNA; ADENOASSOCIATED VIRUS; VIRAL VECTOR; T-CELLS; CLINICAL TRANSLATION; HEMATOPOIETIC STEM; CATIONIC LIPIDS; OPEN-LABEL; DNA;
D O I：
10.1021/acsabm.3c00886
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In medicine, it is desirable for clinicians to be able to restore function and imbue novel function into selected cells for therapy and disease prevention. Cells damaged by disease, injury, or aging could be programmed to restore normal or lost functions, such as retinal cells in inherited blindness and neuronal cells in Alzheimer's disease. Cells could also be genetically programmed with novel functions such as immune cells expressing synthetic chimeric antigen receptors for immunotherapy. Furthermore, knockdown or modification of risk factor proteins can mitigate disease development. Currently, nucleic acids are emerging as a versatile and potent therapeutic modality for achieving this cellular programming. In this review, we highlight the latest developments in nanobiomaterials-based nucleic acid therapeutics for cellular programming from a biomaterial design and delivery perspective and how to overcome barriers to their clinical translation to benefit patients.
引用
收藏
页码：5020 / 5036
页数：17
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