HLA-A,-B,-C,-DPB1,-DQB1 and-DRB1 allele frequencies of North Tanzanian Maasai

被引：0
|
作者：
Barton, Amber [1 ]
Ramadhani, Athumani [2 ]
Mafuru, Elias [2 ]
Mtuy, Tara [1 ,2 ]
Massae, Patrick [2 ]
Malissa, Aiweda [2 ]
Derrick, Tamsyn [1 ,2 ]
Houghton, Joanna [1 ]
Harte, Anna [1 ]
Payne, Thomas [1 ]
Pickering, Harry [1 ]
Burton, Matthew J. [1 ]
Roberts, Chrissy H. [1 ]
Holland, Martin J. [1 ]
机构：
[1] London Sch Hyg & Trop Med, Fac Infect & Tropiclal Dis, Clin Res Dept, London, England
[2] Kilimanjaro Christian Med Ctr, Eye Hlth Project, Moshi, Tanzania
来源：
HUMAN IMMUNOLOGY | 2023年 / 84卷 / 02期
基金：
英国惠康基金; 欧盟地平线“2020”;
关键词：
HLA; MHC; Tanzania; Maasai; Immunogenetics;
D O I：
10.1016/j.humimm.2022.10.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Locus-specific amplicon sequencing was used to HLA type 336 participants of Maasai ethnicity at the HLA-A,-B,-C,-DRB1,-DQB1 and-DPB1 loci. Participants were recruited from three study villages in North Tanzania, for the purpose of investigating risk factors for trachomatous scarring in children. Other than HLA-A, all loci significantly deviated from Hardy-Weinberg equilibrium, possibly due to high relatedness between individuals: 238 individuals shared a house with at least one another participant. The most frequent allele for each locus were A*68:02 (14.3 %), B*53:01 (8.4 %), C*06:02 (19.2 %), DRB1*13:02 (17.7 %), DQB1*02:01 (16.9 %) and DPB1*01:01 (15.7 %), while the most common inferred haplotype was A*68:02 B*18:01 C*07:04 DRB1*08:04 DQB1*04:02 DPB1*04:01 (1.3 %).
引用
收藏
页码：67 / 68
页数：2
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