An unexpected reaction of indole derivatives and EAA catalyzed with InCl3

被引：0

作者：

Wang, Zunyuan ^{[1
,2
]}

Li, Xiaoyu ^{[1
]}

Pan, Youlu ^{[1
]}

Ma, Zhen ^{[1
]}

Shen, Zhengrong ^{[1
,2
]}

Huang, Wenhai ^{[1
,2
]}

机构：

[1] Hangzhou Med Coll, Inst Mat Med, Hangzhou 310013, Peoples R China

[2] Hangzhou Med Coll, Key Lab Neuropsychiat Drug Res Zhejiang Prov, Hangzhou 310013, Peoples R China

来源：

MOLECULAR CATALYSIS | 2023年 / 540卷

关键词：

Indole derivatives; Ethyl acetoacetate; Indium(III) chloride; Cyclobutenes; CYCLOADDITIONS; CYCLOBUTENES; MECHANISM; COUPLINGS; DIENES; INDIUM;

D O I：

10.1016/j.mcat.2023.113065

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

When indole derivatives reacted with ethyl acetoacetate (EAA) using Indium(III) chloride (InCl3) as a catalyst, cyclobutenes were obtained unexpectedly. The structure was identified by 2D-NMR and HRMS. Thus our data maybe established a new method to synthesize cyclobutenes, at least for the indole based cyclobutenes. A plausible mechanism for this surprising reaction was also proposed.

引用

页数：5

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